Pesquisa | Portal de Pesquisa da BVS

1.

Cancer Treatment in the Genomic Era.

Doherty, Gary J; Petruzzelli, Michele; Beddowes, Emma; Ahmad, Saif S; Caldas, Carlos; Gilbertson, Richard J.

Annu Rev Biochem ; 88: 247-280, 2019 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-30901264

2.

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

Man, Si Ming; Zhu, Qifan; Zhu, Liqin; Liu, Zhiping; Karki, Rajendra; Malik, Ankit; Sharma, Deepika; Li, Liyuan; Malireddi, R K Subbarao; Gurung, Prajwal; Neale, Geoffrey; Olsen, Scott R; Carter, Robert A; McGoldrick, Daniel J; Wu, Gang; Finkelstein, David; Vogel, Peter; Gilbertson, Richard J; Kanneganti, Thirumala-Devi.

Cell ; 162(1): 45-58, 2015 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-26095253

3.

Primary cilia control translation and the cell cycle in medulloblastoma.

Youn, Yong Ha; Hou, Shirui; Wu, Chang-Chih; Kawauchi, Daisuke; Orr, Brent A; Robinson, Giles W; Finkelstein, David; Taketo, Makoto M; Gilbertson, Richard J; Roussel, Martine F; Han, Young-Goo.

Genes Dev ; 36(11-12): 737-751, 2022 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-35798383

4.

Driving glioblastoma to drink.

Gilbertson, Richard J.

Cell ; 157(2): 289-290, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24725398

5.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.

Luo, Zaili; Xia, Mingyang; Shi, Wei; Zhao, Chuntao; Wang, Jiajia; Xin, Dazhuan; Dong, Xinran; Xiong, Yu; Zhang, Feng; Berry, Kalen; Ogurek, Sean; Liu, Xuezhao; Rao, Rohit; Xing, Rui; Wu, Lai Man Natalie; Cui, Siying; Xu, Lingli; Lin, Yifeng; Ma, Wenkun; Tian, Shuaiwei; Xie, Qi; Zhang, Li; Xin, Mei; Wang, Xiaotao; Yue, Feng; Zheng, Haizi; Liu, Yaping; Stevenson, Charles B; de Blank, Peter; Perentesis, John P; Gilbertson, Richard J; Li, Hao; Ma, Jie; Zhou, Wenhao; Taylor, Michael D; Lu, Q Richard.

Nature ; 612(7941): 787-794, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36450980

6.

Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis.

Szulzewsky, Frank; Arora, Sonali; Hoellerbauer, Pia; King, Claire; Nathan, Erica; Chan, Marina; Cimino, Patrick J; Ozawa, Tatsuya; Kawauchi, Daisuke; Pajtler, Kristian W; Gilbertson, Richard J; Paddison, Patrick J; Vasioukhin, Valeri; Gujral, Taranjit S; Holland, Eric C.

Genes Dev ; 34(15-16): 1051-1064, 2020 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-32675324

7.

Mapping cancer origins.

Gilbertson, Richard J.

Cell ; 145(1): 25-9, 2011 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-21458665

8.

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Samir, Parimal; Kesavardhana, Sannula; Patmore, Deanna M; Gingras, Sebastien; Malireddi, R K Subbarao; Karki, Rajendra; Guy, Clifford S; Briard, Benoit; Place, David E; Bhattacharya, Anannya; Sharma, Bhesh Raj; Nourse, Amanda; King, Sharon V; Pitre, Aaron; Burton, Amanda R; Pelletier, Stephane; Gilbertson, Richard J; Kanneganti, Thirumala-Devi.

Nature ; 573(7775): 590-594, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31511697

9.

Harnessing brain development to understand brain tumours.

Marino, Silvia; Gilbertson, Richard J.

Development ; 148(2)2021 01 20.

Artigo em Inglês | MEDLINE | ID: mdl-33472850

10.

C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.

Parker, Matthew; Mohankumar, Kumarasamypet M; Punchihewa, Chandanamali; Weinlich, Ricardo; Dalton, James D; Li, Yongjin; Lee, Ryan; Tatevossian, Ruth G; Phoenix, Timothy N; Thiruvenkatam, Radhika; White, Elsie; Tang, Bo; Orisme, Wilda; Gupta, Kirti; Rusch, Michael; Chen, Xiang; Li, Yuxin; Nagahawhatte, Panduka; Hedlund, Erin; Finkelstein, David; Wu, Gang; Shurtleff, Sheila; Easton, John; Boggs, Kristy; Yergeau, Donald; Vadodaria, Bhavin; Mulder, Heather L; Becksfort, Jared; Becksford, Jared; Gupta, Pankaj; Huether, Robert; Ma, Jing; Song, Guangchun; Gajjar, Amar; Merchant, Thomas; Boop, Frederick; Smith, Amy A; Ding, Li; Lu, Charles; Ochoa, Kerri; Zhao, David; Fulton, Robert S; Fulton, Lucinda L; Mardis, Elaine R; Wilson, Richard K; Downing, James R; Green, Douglas R; Zhang, Jinghui; Ellison, David W; Gilbertson, Richard J.

Nature ; 506(7489): 451-5, 2014 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-24553141

11.

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial.

Robinson, Giles W; Rudneva, Vasilisa A; Buchhalter, Ivo; Billups, Catherine A; Waszak, Sebastian M; Smith, Kyle S; Bowers, Daniel C; Bendel, Anne; Fisher, Paul G; Partap, Sonia; Crawford, John R; Hassall, Tim; Indelicato, Daniel J; Boop, Frederick; Klimo, Paul; Sabin, Noah D; Patay, Zoltan; Merchant, Thomas E; Stewart, Clinton F; Orr, Brent A; Korbel, Jan O; Jones, David T W; Sharma, Tanvi; Lichter, Peter; Kool, Marcel; Korshunov, Andrey; Pfister, Stefan M; Gilbertson, Richard J; Sanders, Robert P; Onar-Thomas, Arzu; Ellison, David W; Gajjar, Amar; Northcott, Paul A.

Lancet Oncol ; 19(6): 768-784, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29778738

12.

Novel mutations target distinct subgroups of medulloblastoma.

Robinson, Giles; Parker, Matthew; Kranenburg, Tanya A; Lu, Charles; Chen, Xiang; Ding, Li; Phoenix, Timothy N; Hedlund, Erin; Wei, Lei; Zhu, Xiaoyan; Chalhoub, Nader; Baker, Suzanne J; Huether, Robert; Kriwacki, Richard; Curley, Natasha; Thiruvenkatam, Radhika; Wang, Jianmin; Wu, Gang; Rusch, Michael; Hong, Xin; Becksfort, Jared; Gupta, Pankaj; Ma, Jing; Easton, John; Vadodaria, Bhavin; Onar-Thomas, Arzu; Lin, Tong; Li, Shaoyi; Pounds, Stanley; Paugh, Steven; Zhao, David; Kawauchi, Daisuke; Roussel, Martine F; Finkelstein, David; Ellison, David W; Lau, Ching C; Bouffet, Eric; Hassall, Tim; Gururangan, Sridharan; Cohn, Richard; Fulton, Robert S; Fulton, Lucinda L; Dooling, David J; Ochoa, Kerri; Gajjar, Amar; Mardis, Elaine R; Wilson, Richard K; Downing, James R; Zhang, Jinghui; Gilbertson, Richard J.

Nature ; 488(7409): 43-8, 2012 Aug 02.

Artigo em Inglês | MEDLINE | ID: mdl-22722829

13.

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants.

Pajtler, Kristian W; Mack, Stephen C; Ramaswamy, Vijay; Smith, Christian A; Witt, Hendrik; Smith, Amy; Hansford, Jordan R; von Hoff, Katja; Wright, Karen D; Hwang, Eugene; Frappaz, Didier; Kanemura, Yonehiro; Massimino, Maura; Faure-Conter, Cécile; Modena, Piergiorgio; Tabori, Uri; Warren, Katherine E; Holland, Eric C; Ichimura, Koichi; Giangaspero, Felice; Castel, David; von Deimling, Andreas; Kool, Marcel; Dirks, Peter B; Grundy, Richard G; Foreman, Nicholas K; Gajjar, Amar; Korshunov, Andrey; Finlay, Jonathan; Gilbertson, Richard J; Ellison, David W; Aldape, Kenneth D; Merchant, Thomas E; Bouffet, Eric; Pfister, Stefan M; Taylor, Michael D.

Acta Neuropathol ; 133(1): 5-12, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27858204

14.

Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study.

Patel, Yogesh T; Jacus, Megan O; Davis, Abigail D; Boulos, Nidal; Turner, David C; Vuppala, Pradeep K; Freeman, Burgess B; Gilbertson, Richard J; Stewart, Clinton F.

Drug Metab Dispos ; 44(4): 591-4, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26802130

15.

Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.

Morfouace, Marie; Nimmervoll, Birgit; Boulos, Nidal; Patel, Yogesh T; Shelat, Anang; Freeman, Burgess B; Robinson, Giles W; Wright, Karen; Gajjar, Amar; Stewart, Clinton F; Gilbertson, Richard J; Roussel, Martine F.

J Neurooncol ; 126(2): 225-34, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26518542

16.

Cross-species genomics matches driver mutations and cell compartments to model ependymoma.

Johnson, Robert A; Wright, Karen D; Poppleton, Helen; Mohankumar, Kumarasamypet M; Finkelstein, David; Pounds, Stanley B; Rand, Vikki; Leary, Sarah E S; White, Elsie; Eden, Christopher; Hogg, Twala; Northcott, Paul; Mack, Stephen; Neale, Geoffrey; Wang, Yong-Dong; Coyle, Beth; Atkinson, Jennifer; DeWire, Mariko; Kranenburg, Tanya A; Gillespie, Yancey; Allen, Jeffrey C; Merchant, Thomas; Boop, Fredrick A; Sanford, Robert A; Gajjar, Amar; Ellison, David W; Taylor, Michael D; Grundy, Richard G; Gilbertson, Richard J.

Nature ; 466(7306): 632-6, 2010 Jul 29.

Artigo em Inglês | MEDLINE | ID: mdl-20639864

17.

Subtypes of medulloblastoma have distinct developmental origins.

Gibson, Paul; Tong, Yiai; Robinson, Giles; Thompson, Margaret C; Currle, D Spencer; Eden, Christopher; Kranenburg, Tanya A; Hogg, Twala; Poppleton, Helen; Martin, Julie; Finkelstein, David; Pounds, Stanley; Weiss, Aaron; Patay, Zoltan; Scoggins, Matthew; Ogg, Robert; Pei, Yanxin; Yang, Zeng-Jie; Brun, Sonja; Lee, Youngsoo; Zindy, Frederique; Lindsey, Janet C; Taketo, Makoto M; Boop, Frederick A; Sanford, Robert A; Gajjar, Amar; Clifford, Steven C; Roussel, Martine F; McKinnon, Peter J; Gutmann, David H; Ellison, David W; Wechsler-Reya, Robert; Gilbertson, Richard J.

Nature ; 468(7327): 1095-9, 2010 Dec 23.

Artigo em Inglês | MEDLINE | ID: mdl-21150899

18.

Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects.

Zhu, Guo; Chow, Lionel M L; Bayazitov, Ildar T; Tong, Yiai; Gilbertson, Richard J; Zakharenko, Stanislav S; Solecki, David J; Baker, Suzanne J.

Development ; 139(18): 3422-31, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22874917

19.

WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum.

Pei, Yanxin; Brun, Sonja N; Markant, Shirley L; Lento, William; Gibson, Paul; Taketo, Makoto M; Giovannini, Marco; Gilbertson, Richard J; Wechsler-Reya, Robert J.

Development ; 139(10): 1724-33, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22461560

20.

A perivascular niche for brain tumor stem cells.

Calabrese, Christopher; Poppleton, Helen; Kocak, Mehmet; Hogg, Twala L; Fuller, Christine; Hamner, Blair; Oh, Eun Young; Gaber, M Waleed; Finklestein, David; Allen, Meredith; Frank, Adrian; Bayazitov, Ildar T; Zakharenko, Stanislav S; Gajjar, Amar; Davidoff, Andrew; Gilbertson, Richard J.

Cancer Cell ; 11(1): 69-82, 2007 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-17222791

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