RESUMO
SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4'-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluorination of the phenyl found in Hygromycin A, are discussed.
Assuntos
Antibacterianos/química , Cinamatos/química , Dioxóis/química , Higromicina B/análogos & derivados , Administração Oral , Animais , Antibacterianos/síntese química , Antibacterianos/farmacocinética , Cães , Avaliação Pré-Clínica de Medicamentos , Haplorrinos , Higromicina B/química , Camundongos , Testes de Sensibilidade Microbiana , Ratos , Relação Estrutura-AtividadeRESUMO
We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its activity to the activities of linezolid, quinupristin-dalfopristin, and vancomycin. CE-156811 demonstrated robust in vitro activity against gram-positive bacteria that was comparable to that of linezolid.
Assuntos
Antibacterianos/farmacologia , Cinamatos/farmacologia , Dioxóis/farmacologia , Bactérias Gram-Positivas/efeitos dos fármacos , Higromicina B/análogos & derivados , Acetamidas/farmacologia , Antibacterianos/química , Cinamatos/química , Dioxóis/química , Farmacorresistência Bacteriana Múltipla , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Negativas/isolamento & purificação , Bactérias Gram-Positivas/isolamento & purificação , Humanos , Higromicina B/química , Higromicina B/farmacologia , Técnicas In Vitro , Linezolida , Testes de Sensibilidade Microbiana , Estrutura Molecular , Oxazolidinonas/farmacologiaRESUMO
Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safety concerns, hepatotoxicity in particular. We have discovered a novel series of azetidinyl ketolides that focus on mitigation of hepatotoxicity by minimizing hepatic turnover and time-dependent inactivation of CYP3A isoforms in the liver without compromising the potency and efficacy of 1.