Detalhe da pesquisa
1.
Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.
Drug Metab Dispos
; 47(2): 104-113, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30442650
2.
Metabolism and Disposition of Verinurad, a Uric Acid Reabsorption Inhibitor, in Humans.
Drug Metab Dispos
; 46(5): 532-541, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29490903
3.
6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.
Bioorg Med Chem Lett
; 21(2): 760-3, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21185178
4.
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.
Arthritis Res Ther
; 18(1): 214, 2016 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27716403
5.
Design, synthesis, and antiviral activity of adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus.
J Med Chem
; 48(8): 2867-75, 2005 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15828825
6.
Determination by Multi-NMR Studies of New Stable Aluminum Complexes with Pyrophosphate and Fluoride in Aqueous Solution.
Inorg Chem
; 38(21): 4765-4770, 1999 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-11671203
7.
Synthesis of nucleoside libraries on solid support. I. N2,N6-disubstituted diaminopurine nucleosides.
Nucleosides Nucleotides Nucleic Acids
; 23(1-2): 495-9, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15043169
8.
Synthesis of nucleoside libraries on solid support. II. 2,6,8-Trisubstituted purine nucleosides using 8-bromoguanosine as precursor.
Nucleosides Nucleotides Nucleic Acids
; 23(1-2): 501-7, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15043170
9.
Erratum to: Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.
Arthritis Res Ther
; 18(1): 236, 2016 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27733209
10.
Design and evaluation of a potential mutagen for Hepatitis C virus.
Bioorg Med Chem Lett
; 17(18): 5261-4, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17689246
11.
Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.
Bioorg Chem
; 35(1): 25-34, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16945403
12.
Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication.
Bioorg Med Chem Lett
; 17(9): 2452-5, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17331721
13.
A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 51(2): 429-37, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17116677
14.
6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis C virus inhibitors.
Bioorg Med Chem Lett
; 17(9): 2456-8, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17331718
15.
Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.
Bioorg Chem
; 34(1): 26-38, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16360193
16.
Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.
Antimicrob Agents Chemother
; 50(8): 2772-81, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16870771
17.
Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase.
Bioorg Med Chem Lett
; 16(17): 4444-9, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16806925
18.
Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors.
Bioorg Med Chem Lett
; 15(3): 725-7, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664845
19.
Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase.
Bioorg Med Chem Lett
; 15(3): 675-8, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664835
20.
Synthesis of 9-(2-beta-C-methyl-beta-d-ribofuranosyl)-6-substituted purine derivatives as inhibitors of HCV RNA replication.
Bioorg Med Chem Lett
; 15(3): 709-13, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664842