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2.
Allergol Immunopathol (Madr) ; 14(5): 419-21, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-3799410

RESUMO

Anaphylaxis is a systemic reaction which can be very dangerous in many patients. In addition to the most common antigens (drugs, venoms, foods), physical exercise can provoke anaphylaxis in the sensitized patients. The mechanism of this reaction is still unknown. In this report, we describe a case of exercise-induced anaphylaxis in a 25 year old female who had experienced two syncopal attacks during strong physical activity. On other occasions she had noticed that prolonged work would cause urticaria, pruritus and numbness. During hospitalization, on two occasions a treadmill stress test induced bronchial spasm, urticaria and hypotension. We believe that the association of urticaria and anaphylaxis would suggest the possible presence of a vasoactive substance released from the mast-cells and basophil leucocytes.


Assuntos
Anafilaxia/etiologia , Esforço Físico , Adulto , Aspirina/efeitos adversos , Basófilos/metabolismo , Espasmo Brônquico/etiologia , Hipersensibilidade a Drogas/etiologia , Feminino , Humanos , Hipotensão/etiologia , Mastócitos/metabolismo , Síncope/etiologia , Urticária/induzido quimicamente , Urticária/etiologia
3.
Int J Obes Relat Metab Disord ; 26(3): 370-5, 2002 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11896492

RESUMO

OBJECTIVE: To investigate the possible associations between sleep apnea syndrome, hyperinsulinemia/insulin resistance and hyperleptinemia in subjects with different degrees of body mass index. DESIGN: To test for the presence or absence of sleep apnea syndrome in association with hyperinsulinemia/insulin resistance and hyperleptinemia. SUBJECTS: Twenty subjects with different body mass index (mean BMI 30.9+/-4.2). MEASUREMENTS: Insulin action and plasma soluble leptin receptor were measured by euglycemic hyperinsulinemic glucose clamp and by ELISA method, respectively. Occurrence of sleep apnea syndrome was assessed by clinical and nocturnal monitoring using a validated sleep apnea recorder. RESULTS: The apnea/hypopnea index (AHI) was positively correlated with plasma soluble leptin receptor (0.76; P<0.001) and negatively with the degree of insulin-mediated glucose uptake (r=-0.73; P<0.001). In a multivariate analysis AHI was associated with plasma soluble leptin receptor and insulin mediated glucose uptake independently of age, gender, BMI, plasma leptin levels and PaCO(2). CONCLUSION: Sleep apnea syndrome is associated with plasma soluble leptin receptor and insulin resistance independently of BMI.


Assuntos
Proteínas de Transporte/sangue , Resistência à Insulina , Receptores de Superfície Celular , Síndromes da Apneia do Sono/etiologia , Adulto , Índice de Massa Corporal , Dióxido de Carbono/análise , Ensaio de Imunoadsorção Enzimática , Feminino , Técnica Clamp de Glucose , Humanos , Insulina/sangue , Leptina/sangue , Masculino , Pessoa de Meia-Idade , Receptores para Leptina , Solubilidade , Triglicerídeos/sangue
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