Targeting NF-κB signaling pathway in cancer by dietary polyphenols.

Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-κB signaling pathway. They depress the phosphorylation of kinases, inhibit NF-κB translocate into the nucleus as well as interfere interactions between NF-κB and DNA. Through inhibition of NF-κB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-κB signaling pathway regulation.

Personal trust extends cooperation beyond trustees: A Mexican study.

We studied 2 groups of workers from Oaxaca (Mexico) with different levels of income and education to investigate the role that the affective-based psychological mechanism of personal trust, as evolutionarily acquired, plays on group cooperation. We measured trust levels through some questionnaires and cooperative behaviour through an iterated prisoner's dilemma under different conditions and analysed trust networks of group members. While these groups did not differ in trust levels or cooperation among trustees, they did differ in terms of cooperation with other group members. Such differences are related to dissimilarities in the trust network topology-as a measure of group cohesion. These results suggest that some personal trust networks extend cooperation within a group beyond trustees in a way that complements the role of the reputation for indirect reciprocity.

Externalization is common to all value judgments, and norms are motivating because of their intersubjective grounding.

We show that externalization is a feature not only of moral judgment, but also of value judgment in general. It follows that the evolution of externalization was not specific to moral judgment. Second, we argue that value judgments cannot be decoupled from the level of motivations and preferences, which, in the moral case, rely on intersubjective bonds and claims.

Testing the cultural group selection hypothesis in Northern Ghana and Oaxaca.

We examine the cultural group selection (CGS) hypothesis in light of our fieldwork in Northern Ghana and Oaxaca, highly multi-ethnic regions. Our evidence fails to corroborate two central predictions of the hypothesis: that the cultural group is the unit of evolution, and that cultural homogenization is to be expected as the outcome of a selective process.

Credibility, credulity, and redistribution.

After raising some doubts for cultural group selection as an explanation of prosocial religiosity, we propose an alternative that views it as a "greenbeard effect." We combine the dynamic constraints on the evolution of greenbeard effects with Iannaccone's (1994) account of strict sects. Our model shows that certain social conditions may foster credulity and prosociality.

Moving beyond the lab: investigating empathy through the Empirical 5E approach.

Empathy is a complex and multifaceted phenomenon that plays a crucial role in human social interactions. Recent developments in social neuroscience have provided valuable insights into the neural underpinnings and bodily mechanisms underlying empathy. This methodology often prioritizes precision, replicability, internal validity, and confound control. However, fully understanding the complexity of empathy seems unattainable by solely relying on artificial and controlled laboratory settings, while overlooking a comprehensive view of empathy through an ecological experimental approach. In this article, we propose articulating an integrative theoretical and methodological framework based on the 5E approach (the "E"s stand for embodied, embedded, enacted, emotional, and extended perspectives of empathy), highlighting the relevance of studying empathy as an active interaction between embodied agents, embedded in a shared real-world environment. In addition, we illustrate how a novel multimodal approach including mobile brain and body imaging (MoBi) combined with phenomenological methods, and the implementation of interactive paradigms in a natural context, are adequate procedures to study empathy from the 5E approach. In doing so, we present the Empirical 5E approach (E5E) as an integrative scientific framework to bridge brain/body and phenomenological attributes in an interbody interactive setting. Progressing toward an E5E approach can be crucial to understanding empathy in accordance with the complexity of how it is experienced in the real world.

Evidence of recursion in tool use.

We discuss the discovery of technologies involving knotted netting, such as textiles, basketry, and cordage, in the Upper Paleolithic. This evidence, in our view, suggests a new way of connecting toolmaking and syntactic structure in human evolution, because these technologies already exhibit an "infinite use of finite means," which we take to constitute the key transition to human cognition.

Emotional contagion in nonhuman animals: A review.

Emotional contagion, the emotional state-matching of an individual with another, seems to be crucial for many social species. In recent years evidence on emotional contagion in different animal species has accumulated. However, despite its adaptative advantages and its presumed simplicity, the study and direct demonstration of this phenomenon present more complexities than previously thought. For these reasons, a review of the literature on emotional contagion in nonhuman species is timely to integrate current findings. In this paper thus, we carry out a comprehensive review of the most relevant studies on emotional contagion in animals and discuss the main problems and challenges of the field. We conclude that more research is needed to broaden our understanding of the mechanisms and functions of emotional contagion and the extent to which this process is present in a wide variety of species. Furthermore, the comparative study of emotional contagion would benefit from the use of systematized paradigms including both behavioral and physiological measures and the simultaneous recording of the responses of the interacting individuals to reliably assess an emotional state-matching between them and reliable controls. This article is categorized under: Cognitive Biology > Evolutionary Roots of Cognition Psychology > Comparative Psychology Psychology > Emotion and Motivation.

The study of aggression and affiliation motifs in bottlenose dolphins' social networks.

Networks in biology have provided a powerful tool to describe and study very complex biological processes and systems such as animal societies. Social network analysis allows us to assess different processes occurring in animal groups. In the current study, we use this approach to investigate how conflict dynamics and post-conflict interactions shape the social networks of groups of captive bottlenose dolphins. We first examined temporal changes and aggression-affiliation motifs in the observed dolphins' network structure. Using the results of the previous analysis, we built two models that simulate the dynamics of aggression and affiliation in a small dolphin group. The first model is based only on the observed statistics of interactions, whereas the second includes post conflict memory effects as well. We found that the resulting social networks and their most common motifs matched the association patterns observed in wild and captive dolphins. Furthermore, the model with memory was able to capture the observed dynamics of this group of dolphins. Thus, our models suggest the presence and influence of post-conflict behaviors on the structure of captive dolphins' social networks. Therefore, the network approach reveals as an effective method to define animal social networks and study animal sociality. Finally, this approach can have important applications in the management of animal populations in captive settings.

Infants' performance in the indirect false belief tasks: A second-person interpretation.

Research in the last 15 years has challenged the idea that false belief attribution develops at 4 years of age. Studies with indirect false belief tasks contend to provide evidence of false belief attribution in the second year of life. We review the literature on indirect false belief tasks carried out in infants using looking and active helping paradigms. Although the results are heterogeneous and not conclusive, such tasks appear to capture a real effect. However, it is misleading to call them "false belief" tasks, as it is possible to pass them without making any false belief attribution. Infants need to keep track of the object's and agent's positions, trajectories, and focus of attention, given an intentional understanding of the agent, to pass these new tasks. We, therefore, argue that the evidence can be better explained in terms of second-person attributions, which are transparent, extensional, nonpropositional, reciprocally contingent, and implicit. Second-person attributions can also account for primates' mentalizing abilities, as revealed by similar indirect tasks. This article is categorized under: Cognitive Biology > Cognitive Development Philosophy > Foundations of Cognitive Science Cognitive Biology > Evolutionary Roots of Cognition.

Naturalizing Darwall's Second Person Standpoint.

In this paper, we take Darwall's analytical project of the second-person standpoint as the starting point for a naturalistic project about our moral psychology. In his project, Darwall contends that our moral notions constitutively imply the perspective of second-personal interaction, i.e. the interaction of two mutually recognized agents who make and acknowledge claims on one another. This allows him to explain the distinctive purported authority of morality. Yet a naturalized interpretation of it has potential as an account of our moral psychology. We propose a naturalistic interpretation of Darwall's work to address some of the main issues about our moral psychology. First, we explain why moral norms motivate us; namely, because of these second-personal relations. We provide a naturalized version of this solution. Second, we articulate how intersubjective interactions take place effectively; grounding duties to particular other subjects, and being related to distinctive moral emotions. Third, we address the question of the limits of the moral community, proposing that it comprises all agents capable of second-personal interactions. Finally, we explain the emergence of community norms through intersubjective interaction. Since all group members can adopt alternatively the second-personal stance to each other, demands are sanctioned and recognized in a triangulation process which explains the emergence of group norms.

A Minimal Turing Test: Reciprocal Sensorimotor Contingencies for Interaction Detection.

In the classical Turing test, participants are challenged to tell whether they are interacting with another human being or with a machine. The way the interaction takes place is not direct, but a distant conversation through computer screen messages. Basic forms of interaction are face-to-face and embodied, context-dependent and based on the detection of reciprocal sensorimotor contingencies. Our idea is that interaction detection requires the integration of proprioceptive and interoceptive patterns with sensorimotor patterns, within quite short time lapses, so that they appear as mutually contingent, as reciprocal. In other words, the experience of interaction takes place when sensorimotor patterns are contingent upon one's own movements, and vice versa. I react to your movement, you react to mine. When I notice both components, I come to experience an interaction. Therefore, we designed a "minimal" Turing test to investigate how much information is required to detect these reciprocal sensorimotor contingencies. Using a new version of the perceptual crossing paradigm, we tested whether participants resorted to interaction detection to tell apart human from machine agents in repeated encounters with these agents. In two studies, we presented participants with movements of a human agent, either online or offline, and movements of a computerized oscillatory agent in three different blocks. In each block, either auditory or audiovisual feedback was provided along each trial. Analysis of participants' explicit responses and of the implicit information subsumed in the dynamics of their series will reveal evidence that participants use the reciprocal sensorimotor contingencies within short time windows. For a machine to pass this minimal Turing test, it should be able to generate this sort of reciprocal contingencies.

Moral reasoning and moral conflict in patients of the amyotrophic lateral sclerosis - Frontotemporal dementia spectrum.

The aim of this study was to investigate the moral reasoning and moral conflict in patients of the amyotrophic lateral sclerosis - frontotemporal dementia (ALSFTD) spectrum. Ten ALS patients without cognitive impairment, 10 ALS patients with cognitive or behavioral impairment, 10 ALSFTD patients and 23 controls were examined with neuropsychological and behavioral tests as well as with a set of eight well -designed moral dilemmas. The responses to the moral dilemmas were used as proxies to evaluate interpersonal moral reasoning. Reactivity to change, reaction time and arousal were used as markers of moral conflict. ALSFTD patients showed more "utilitarian" responses and less moral conflict than control participants. ALS patients without dementia showed a trend toward slower reaction time, which could be largely attributed to physical disability. No significant changes in arousal were found in ALS patients compared with control participants. Behavioral changes (apathy and dysexecutive symptoms) were partly responsible for the changes found in patients of the ALSFTD spectrum. Our results suggest that most ALS patients without dementia, but not those with concomitant dementia, would be able to deal with the conflict of complex moral decisions, such as end-of-life decisions, at least in mild to moderate stages of the disease.

A Practice-Inspired Mindset for Researching the Psychophysiological and Medical Health Effects of Recreational Dance (Dance Sport).

"Dance" has been associated with many psychophysiological and medical health effects. However, varying definitions of what constitute "dance" have led to a rather heterogenous body of evidence about such potential effects, leaving the picture piecemeal at best. It remains unclear what exact parameters may be driving positive effects. We believe that this heterogeneity of evidence is partly due to a lack of a clear definition of dance for such empirical purposes. A differentiation is needed between (a) the effects on the individual when the activity of "dancing" is enjoyed as a dancer within different dance domains (e.g., professional/"high-art" type of dance, erotic dance, religious dance, club dancing, Dance Movement Therapy (DMT), and what is commonly known as hobby, recreational or social dance), and (b) the effects on the individual within these different domains, as a dancer of the different dance styles (solo dance, partnering dance, group dance; and all the different styles within these). Another separate category of dance engagement is, not as a dancer, but as a spectator of all of the above. "Watching dance" as part of an audience has its own set of psychophysiological and neurocognitive effects on the individual, and depends on the context where dance is witnessed. With the help of dance professionals, we first outline some different dance domains and dance styles, and outline aspects that differentiate them, and that may, therefore, cause differential empirical findings when compared regardless (e.g., amount of interpersonal contact, physical exertion, context, cognitive demand, type of movements, complexity of technique and ratio of choreography/improvisation). Then, we outline commonalities between all dance styles. We identify six basic components that are part of any dance practice, as part of a continuum, and review and discuss available research for each of them concerning the possible health and wellbeing effects of each of these components, and how they may relate to the psychophysiological and health effects that are reported for "dancing": (1) rhythm and music, (2) sociality, (3) technique and fitness, (4) connection and connectedness (self-intimation), (5) flow and mindfulness, (6) aesthetic emotions and imagination. Future research efforts might take into account the important differences between types of dance activities, as well as the six components, for a more targeted assessment of how "dancing" affects the human body.

Differential Effects of Varying Concentrations of Phosphorus, Iron, and Nitrogen in N2-Fixing Cyanobacteria.

Diazotrophs or N2-fixers are one of the most ecologically significant groups in marine ecosystems (pelagic and benthic). Inorganic phosphorus (PO4 3-) and iron (Fe) can limit the growth and N2-fixing capacities of cyanobacteria. However, studies investigating co-limitation of these factors are lacking. Here, we added different concentrations of PO4 3- and Fe in two cyanobacterial species whose relatives can be found in seagrass habitats: the unicellular Halothece sp. (PCC 7418) and the filamentous Fischerella muscicola (PCC 73103), grown under different nitrate (NO3 -) concentrations and under N2 as sole N source, respectively. Their growth, pigment content, N2-fixation rates, oxidative stress responses, and morphological and cellular changes were investigated. Our results show a serial limitation of NO3 - and PO4 3- (with NO3 - as the primary limiting nutrient) for Halothece sp. Simultaneous co-limitation of PO4 3- and Fe was found for both species tested, and high levels of Fe (especially when added with high PO4 3- levels) inhibited the growth of Halothece sp. Nutrient limitation (PO4 3-, Fe, and/or NO3 -) enhanced oxidative stress responses, morphological changes, and apoptosis. Furthermore, an extensive bio-informatic analysis describing the predicted Pho, Fur, and NtcA regulons (involved in the survival of cells to P, Fe, and N limitation) was made using the complete genome of Halothece sp. as a model, showing the potential of this strain to adapt to different nutrient regimes (P, Fe, or N).

Bottlenose dolphins do not behave prosocially in an instrumental helping task.

Although bottlenose dolphins (Tursiops truncatus) are known for being a highly social species that live in complex societies that rely on coalition formation and cooperative behaviours, experimental studies on prosocial behaviour in this species are scarce. Helping others reach their goals (instrumental helping) is considered as an example of prosocial behaviour. Thus, in this pilot study, we examined whether a group of five captive bottlenose dolphins would behave prosocially in an instrumental helping task. Dolphins were given the opportunity to share tokens that allow their partners to obtain a preferred toy. Dolphins were tested in their free time and they could choose to share the tokens or do nothing. None of the dolphins shared the tokens, instead, they preferred to play with them, ignoring their partners. They did transfer the tokens to other sides of the pool but out of the reach of their partners. Therefore, this group of dolphins did not spontaneously help their partners in this task, showing no preference for other-regarding behaviour in this context.

Infants' performance in spontaneous-response false belief tasks: A review and meta-analysis.

Evidence obtained with new experimental paradigms has renewed the debate on the development of theory of mind in general and false belief ascription in particular. Namely, several studies contend to prove that infants already have the capacity to attribute false beliefs. The aim of the current meta-analysis is to review and summarize the empirical evidence about spontaneous-response false belief tasks in infants younger than 2 years old. Fifty-six false belief conditions using the violation-of-expectation, the anticipatory looking and interactive paradigms were included in this meta-analysis, including 1469 infants. The role of several moderators was examined, following Wellman et al.ös meta-analysis (2001). Results show that correct performance on spontaneous-response false belief tasks was about 1.76 times more likely than incorrect performance (ß = 0.57, 95% CI 0.33; 0.80, p <  .0001). Mediator analyses revealed that (i) year of publication had a significant influence on performance, reducing the average log odds of successful performance (ß = -0.11, 95% CI: -0.16; -0.06, p < .0001); and (ii) correct performance was more likely than incorrect performance when the task was conducted in the violation-of-expectation paradigm (ß = 0.75, 95% CI: 0.25; 1.26, p =  .003). However, heterogeneity was high across the studies and the funnel plot revealed an asymmetric distribution suggesting that studies with small effect sizes were not published. These results cast doubt on the alleged robustness of the phenomenon: its effect size decreases as time passes, it seems to depend on the type of paradigm employed, and the variance across studies is not well understood yet.

Beneficial effects of word final stress in segmenting a new language: evidence from ERPs.

BACKGROUND: How do listeners manage to recognize words in an unfamiliar language? The physical continuity of the signal, in which real silent pauses between words are lacking, makes it a difficult task. However, there are multiple cues that can be exploited to localize word boundaries and to segment the acoustic signal. In the present study, word-stress was manipulated with statistical information and placed in different syllables within trisyllabic nonsense words to explore the result of the combination of the cues in an online word segmentation task. RESULTS: The behavioral results showed that words were segmented better when stress was placed on the final syllables than when it was placed on the middle or first syllable. The electrophysiological results showed an increase in the amplitude of the P2 component, which seemed to be sensitive to word-stress and its location within words. CONCLUSION: The results demonstrated that listeners can integrate specific prosodic and distributional cues when segmenting speech. An ERP component related to word-stress cues was identified: stressed syllables elicited larger amplitudes in the P2 component than unstressed ones.

On the moral import of the arts: The case of music.

There has been a controversy on the moral import of music and art in general. On the one hand, the moralist view contends that there is some sort of link between art and morality, even if the way to specify this link may be highly diverse. It comprises most of the classical views of art, from Schiller's view of the role of artistic education in moral development, to any view that declares a form of art as corrupt or degenerated, or enlightening. What it is assumed minimally in all of them is that the moral import of an artwork contributes to its aesthetic value. On the other hand, formalist views claim that the aesthetic value of an artwork is genuine and autonomous, and therefore it is independent of any other value. In this chapter we focus on music, as the most difficult case for the moralist standpoint, given the lack of representational content of music. We argue for a variety of the moralist's view according to which the moral import of a musical artwork is not derived from its content (obviously, as it lack any), but from its pragmatics: the context and the intentions that guide its composition and performance, by analogy with any other intentional action, and point to the emotional impact of music as the common ground that bridges moral and aesthetic values. As a provisional conclusion, we outline a research program for brain studies that follows from this proposal, as a way test its predictions, focusing both on the emotional grounds of valuation and their context-dependency.

Preface.

The preface briefly present the motivation of the issue, and introduces the papers that compose the volume.