Natural product drug discovery in the artificial intelligence era.

Natural products (NPs) are primarily recognized as privileged structures to interact with protein drug targets. Their unique characteristics and structural diversity continue to marvel scientists for developing NP-inspired medicines, even though the pharmaceutical industry has largely given up. High-performance computer hardware, extensive storage, accessible software and affordable online education have democratized the use of artificial intelligence (AI) in many sectors and research areas. The last decades have introduced natural language processing and machine learning algorithms, two subfields of AI, to tackle NP drug discovery challenges and open up opportunities. In this article, we review and discuss the rational applications of AI approaches developed to assist in discovering bioactive NPs and capturing the molecular "patterns" of these privileged structures for combinatorial design or target selectivity.

Seasat synthetic aperture radar: ocean wave detection capabilities.

A preliminary assessment has been made of the capability of the Seasat synthetic aperture radar to detect ocean waves. Comparison with surface and aircraft measurements from five passes of the satellite over the Gulf of Alaska indicates agreement to within about - 15 percent in wavelength and about +/- 25 degrees in wave direction. These results apply to waves 100 to 250 meters in length propagating in a direction predominantly across the satellite track, in sea states with significant wave height (H((1/3))) in a range of 2 to 3.5 meters.

Tsunami: scientific frontiers, mitigation, forecasting and policy implications.

Tsunamis are an ever-present threat to lives and property along the coasts of most of the world's oceans. As the Sumatra tsunami of 26 December 2004 reminded the world, we must be more proactive in developing ways to reduce their impact on our global society. This article provides an overview of the state of knowledge of tsunamis, presents some challenges confronting advances in the field and identifies some promising frontiers leading to a global warning system. This overview is then used to develop guidelines for advancing the science of forecasting, hazard mitigation programmes and the development of public policy to realize a global system. Much of the information on mitigation and forecasting draws upon the development and accomplishments of a joint state/federal partnership that was forged to reduce tsunami hazards along US coastlines-the National Tsunami Hazard Mitigation Programme. By integrating hazard assessment, warning guidance and mitigation activities, the programme has created a roadmap and a set of tools to make communities more resilient to local and distant tsunamis. Among the tools are forecasting, educational programmes, early warning systems and design guidance for tsunami-resilient communities. Information on international cooperation is drawn from the Global Earth Observing System of Systems (GEOSS). GEOSS provides an international framework to assure international compatibility and interoperability for rapid exchange of data and information.