RESUMO
In recent years, the cardiovascular manifestations of systemic lupus erythematosus have became more apparent as a consequence of both prolonged survival and improvement in diagnostic modalities. We report the case of a 16-year old woman with systemic lupus erythematosus in whom the presence of cardiomyopathy was characterized by endomyocardial biopsy. This diagnostic technique also showed that the histologic hallmark of lupus myocardiopathy persisted despite corticosteroid and plasmapheresis, suggesting the need of a careful cardiac follow-up in these patients.
Assuntos
Lúpus Eritematoso Sistêmico/complicações , Miocardite/diagnóstico , Adolescente , Corticosteroides/uso terapêutico , Biópsia , Feminino , Humanos , Lúpus Eritematoso Sistêmico/patologia , Miocardite/etiologia , Miocardite/terapia , PlasmafereseRESUMO
The Authors have studied th haemodynamic response of ten normal subjects to the intravenous administration of 160 MRC.U. of Calcitonin in 60 min, by serial measurement of the systolic time intervals. The analysis of results pointed out a minor inotropic effect starting from the 10th minute from the beginning of the infusion. Little but significant decrements (P less than 0.01) in the duration of the pre-ejection phase of the isovolumetric contraction time, as well as a significant increase (P less than 0.01) in the LVET/PEP ratio, have been noted. A negative chronotropic effect (P less than 0.05) has been noted starting from the 30th minute. The mechanism by which Calcitonin can modify the myocardial inotropism in the normal subject is till now unknown, and it could be related to the interference of this hormore on the endocellular movements of Calcium, and on the cellular levels of cyclic AMP.
Assuntos
Calcitonina/farmacologia , Contração Miocárdica/efeitos dos fármacos , Adulto , Pressão Sanguínea/efeitos dos fármacos , Cálcio/sangue , Eletrocardiografia , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Sístole/efeitos dos fármacosRESUMO
In a patient with Wolff-Parkinson-White syndrome and an inferior-posterior bypass tract, transient restoration of normal conduction occurred during an attack of angina. The ECG pattern of inferior posterior ischemia was present when the conduction was normal. Thallium scintigraphy showed a reversible posterolateral perfusion defect. The possible mechanisms for production of intermittent preexcitation are discussed.
Assuntos
Angina Pectoris/diagnóstico , Eletrocardiografia , Sistema de Condução Cardíaco/fisiopatologia , Síndrome de Wolff-Parkinson-White/diagnóstico , Idoso , Angina Pectoris/fisiopatologia , Coração/diagnóstico por imagem , Humanos , Masculino , Cintilografia , Radioisótopos de Tálio , Síndrome de Wolff-Parkinson-White/fisiopatologiaRESUMO
To further investigate the relationship between oophorectomy (OF) and mineral bone loss, 15 women who underwent total hysterectomy and bilateral oophorectomy were studied for 12 months after surgery. Mineralometric and metabolic data were obtained before and after 3, 6, and 12 months. The women lost bone mineral content (measured by single photon absorptiometry) at the same rate they lost cortical and trabecular bone, suggesting that bone loss after OF is a generalized phenomenon. Our data also show that an increase in bone resorption takes place only in the first period after OF; the persistency of a negative bone balance up to 12 months, accompanied by a reduction of osteocalcin serum levels, may be dependent on a reduced bone formation, probably due to osteoblastic insufficiency.
Assuntos
Ácido 1-Carboxiglutâmico/sangue , Proteínas de Ligação ao Cálcio/sangue , Osteoblastos/metabolismo , Osteoporose/etiologia , Ovariectomia/efeitos adversos , Adulto , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Osteocalcina , Osteoporose/sangueRESUMO
Estrogen deficiency after ovariectomy in the rat is followed by an increase of bone turnover and bone loss. Estrogens are thought to modulate the sensitivity of skeleton to Parathyroid Hormone; according to the recently reported evidence of estrogen receptors on osteoblasts, however, a direct effect on bone cells should not be ruled out. We studied the behaviour of Bone Gla Protein (Osteocalcin), a reliable marker of osteoblast function, in growing rats after ovariectomy and treatment with 17 beta-estradiol. Results indicate that ovariectomy stimulates, as expected, bone turnover, and that estrogen induces a further increase of osteoblast activity revealed by the rise of Bone Gla Protein plasma levels. This data may have clinical implications in humans, where estrogens are currently suggested for prevention and therapy of post menopausal osteoporosis.
Assuntos
Osso e Ossos/metabolismo , Proteínas de Ligação ao Cálcio/sangue , Estradiol/farmacologia , Osteoblastos/metabolismo , Ovariectomia , Animais , Biomarcadores , Peso Corporal/efeitos dos fármacos , Reabsorção Óssea/efeitos dos fármacos , Osso e Ossos/análise , Osso e Ossos/citologia , Feminino , Crescimento , Osteocalcina , Osteogênese/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Receptores de Estrogênio/análise , Receptores de Estrogênio/fisiologiaRESUMO
The effect of calcium infusion on osteocalcin(Bone Gla Protein, BGP) serum levels were studied in a group of preterm newborns with bw appropriate for gestational age. Results showed that basal BGP serum levels in preterm newborns are higher than those reported at birth in normal infants. Moreover, calcium infusion induced a significant decrease in BGP values, inversely correlated with serum calcium. Since calcium loading increases both Ca availability for bone formation and BGP affinity for mineral surfaces, reduction of osteocalcin serum levels might reflect a shift of the protein from bloodstream to bone, suggesting an intervention in regulating an effective calcium uptake.