Detalhe da pesquisa
1.
Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation.
J Pharmacol Exp Ther
; 386(1): 4-14, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36958846
2.
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.
Elife
; 112022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35234610
3.
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.
J Med Chem
; 62(21): 9618-9641, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525968
4.
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.
J Med Chem
; 62(2): 908-927, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30499663
5.
Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.
Cell Rep
; 24(12): 3133-3145, 2018 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30231997
6.
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 61(11): 4810-4831, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29737846
7.
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
ACS Med Chem Lett
; 7(3): 277-82, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985315
8.
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science
; 350(6267): aac5464, 2015 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26680203