Detalhe da pesquisa
1.
Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell
; 174(3): 672-687.e27, 2018 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30053426
2.
Conformational coupling across the plasma membrane in activation of the EGF receptor.
Cell
; 152(3): 543-56, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374349
3.
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.
Cell
; 146(5): 732-45, 2011 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21884935
4.
A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane.
Proc Natl Acad Sci U S A
; 119(19): e2122531119, 2022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507881
5.
Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS.
Proc Natl Acad Sci U S A
; 118(45)2021 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34740968
6.
Stochasticity and positive feedback enable enzyme kinetics at the membrane to sense reaction size.
Proc Natl Acad Sci U S A
; 118(47)2021 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34789575
7.
Nanopore-mediated protein delivery enabling three-color single-molecule tracking in living cells.
Proc Natl Acad Sci U S A
; 118(5)2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33495347
8.
Raf promotes dimerization of the Ras G-domain with increased allosteric connections.
Proc Natl Acad Sci U S A
; 118(10)2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33653954
9.
A Membrane-Associated Light-Harvesting Model is Enabled by Functionalized Assemblies of Gene-Doubled TMV Proteins.
Small
; 19(20): e2207805, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36811150
10.
How the T cell signaling network processes information to discriminate between self and agonist ligands.
Proc Natl Acad Sci U S A
; 117(42): 26020-26030, 2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33020303
11.
Competition for shared downstream signaling molecules establishes indirect negative feedback between EGFR and EphA2.
Biophys J
; 121(10): 1897-1908, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35430415
12.
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.
Nat Immunol
; 11(1): 90-6, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20010844
13.
Spatial organization and signal transduction at intercellular junctions.
Nat Rev Mol Cell Biol
; 11(5): 342-52, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20354536
14.
Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction.
Proc Natl Acad Sci U S A
; 116(30): 15013-15022, 2019 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31278151
15.
Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.
Proc Natl Acad Sci U S A
; 116(22): 10798-10803, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31076553
16.
Height, but not binding epitope, affects the potency of synthetic TCR agonists.
Biophys J
; 120(18): 3869-3880, 2021 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34453921
17.
Coupled membrane lipid miscibility and phosphotyrosine-driven protein condensation phase transitions.
Biophys J
; 120(7): 1257-1265, 2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33080222
18.
Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility.
Proc Natl Acad Sci U S A
; 115(25): E5696-E5705, 2018 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29866846
19.
Membrane Association Transforms an Inert Anti-TCRß Fab' Ligand into a Potent T Cell Receptor Agonist.
Biophys J
; 118(12): 2879-2893, 2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407684
20.
Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.
Proc Natl Acad Sci U S A
; 114(46): 12190-12195, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29087297