Detalhe da pesquisa
1.
Ninety-eight semesters of cytochrome P450 enzymes and related topics-What have I taught and learned?
J Biol Chem
; 300(2): 105625, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38185246
2.
The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive.
J Biol Chem
; 300(1): 105495, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38006947
3.
Proteomics, modeling, and fluorescence assays delineate cytochrome b5 residues involved in binding and stimulation of cytochrome P450 17A1 17,20-lyase.
J Biol Chem
; 300(3): 105688, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38280431
4.
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases.
Nucleic Acids Res
; 51(8): 3888-3902, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999602
5.
Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1.
J Biol Chem
; 299(7): 104841, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37209823
6.
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells.
Chem Res Toxicol
; 37(5): 671-674, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38626399
7.
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes.
Arch Toxicol
; 98(6): 1581-1628, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38520539
8.
Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation.
Angew Chem Int Ed Engl
; 63(9): e202317711, 2024 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38206808
9.
Drug Metabolism: A Half-Century Plus of Progress, Continued Needs, and New Opportunities.
Drug Metab Dispos
; 51(1): 99-104, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35868640
10.
Cytochrome P450 enzymes as drug targets in human disease.
Drug Metab Dispos
; 2023 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37793784
11.
3,4-Desaturation of retinoic acid by cytochrome P450 27C1 prevents P450-mediated catabolism.
Arch Biochem Biophys
; 743: 109669, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37356607
12.
Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1.
Chem Res Toxicol
; 36(11): 1778-1788, 2023 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783573
13.
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro.
Xenobiotica
; 53(5): 357-365, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-37584614
14.
DNA polymerases η and κ bypass N2-guanine-O6-alkylguanine DNA alkyltransferase cross-linked DNA-peptides.
J Biol Chem
; 297(4): 101124, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34461101
15.
Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation.
J Biol Chem
; 297(4): 101142, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34480899
16.
Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process.
J Biol Chem
; 296: 100223, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33449875
17.
Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis.
J Biol Chem
; 297(2): 100969, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34273352
18.
Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis.
J Biol Chem
; 296: 100571, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753170
19.
Enzymatic bypass of an N6-deoxyadenosine DNA-ethylene dibromide-peptide cross-link by translesion DNA polymerases.
J Biol Chem
; 296: 100444, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33617883
20.
Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N2-ethenodeoxyguanosine by human DNA translesion polymerase η.
J Biol Chem
; 296: 100642, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33839151