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Can J Microbiol ; 63(7): 644-647, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28460189

RESUMO

Neisseria meningitidis serogroups B and C have been responsible for the majority of invasive meningococcal disease in Australia, with serogroup B strains causing an increasing proportion of cases in recent years. Serogroup Y has typically caused sporadic disease in Australia. In 2002, a cluster of 4 cases was reported from a rural region in Queensland. Three of these cases were serogroup C, with 1 case diagnosed by molecular detection only, and the fourth case was identified as a serogroup Y infection. Genomic analysis, including antigen finetyping, multilocus sequence typing (MLST), and core genome MLST, demonstrated that the serogroup Y case, though spatially and temporally linked to a serogroup C disease cluster, was not the product of a capsule switch and that one of the serogroup C isolates had a deletion of the entire porA sequence.


Assuntos
Surtos de Doenças , Infecções Meningocócicas/microbiologia , Neisseria meningitidis/genética , Porinas/genética , Análise por Conglomerados , Humanos , Infecções Meningocócicas/epidemiologia , Tipagem de Sequências Multilocus , Neisseria meningitidis/imunologia , Neisseria meningitidis/isolamento & purificação , Queensland , Análise de Sequência de DNA , Sorogrupo
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