Detalhe da pesquisa
1.
The role of heparan sulfate maturation in cancer: A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs).
Semin Cancer Biol
; 62: 68-85, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31711992
2.
Biallelic B3GALT6 mutations cause spondylodysplastic Ehlers-Danlos syndrome.
Hum Mol Genet
; 27(20): 3475-3487, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29931299
3.
Synthesis of oligosaccharides of the linkage region of proteoglycans using regioselective glycosylation.
Org Biomol Chem
; 18(25): 4831-4842, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32608461
4.
Synthesis of a library of variously modified 4-methylumbelliferyl xylosides and a structure-activity study of human ß4GalT7.
Org Biomol Chem
; 15(45): 9653-9669, 2017 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29116283
5.
Probing the acceptor active site organization of the human recombinant ß1,4-galactosyltransferase 7 and design of xyloside-based inhibitors.
J Biol Chem
; 290(12): 7658-70, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25568325
6.
Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-syndrome-like connective tissue disorder.
Am J Hum Genet
; 92(6): 935-45, 2013 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664118
7.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.
Glycobiology
; 22(4): 561-71, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22156920
8.
Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway.
J Biol Chem
; 285(48): 37342-58, 2010 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843813
9.
Biochemical and thermodynamic characterization of mutated ß1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers-Danlos syndrome.
Biochem J
; 432(2): 303-11, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20809901
10.
Thermodynamic insights into the structural basis governing the donor substrate recognition by human beta1,4-galactosyltransferase 7.
Biochem J
; 418(3): 605-14, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19032152
11.
A versatile strategy to synthesize N-methyl-anthranilic acid-labelled glycoprobes for fluorescence-based screening assays.
Chem Commun (Camb)
; 56(73): 10746-10749, 2020 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32789356
12.
'Click'-xylosides as initiators of the biosynthesis of glycosaminoglycans: Comparison of mono-xylosides with xylobiosides.
Chem Biol Drug Des
; 89(3): 319-326, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27618481
13.
Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of beta1,3-glucuronosyltransferase I (GlcAT-I).
Protein Sci
; 15(7): 1667-78, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16815917
14.
The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.
Front Cell Neurosci
; 8: 349, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25389387
15.
Modifications of the glycosaminoglycan-linkage region of proteoglycans: phosphorylation and sulfation determine the activity of the human beta1,4-galactosyltransferase 7 and beta1,3-glucuronosyltransferase I.
ScientificWorldJournal
; 5: 510-4, 2005 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16075146
16.
Molecular basis for acceptor substrate specificity of the human beta1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively.
Glycobiology
; 17(8): 857-67, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17567734
17.
Purification and characterization of a soluble form of the recombinant human galactose-beta1,3-glucuronosyltransferase I expressed in the yeast Pichia pastoris.
Protein Expr Purif
; 47(1): 137-43, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16300963
18.
Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
J Biol Chem
; 280(2): 1417-25, 2005 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15522873
19.
The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues.
J Biol Chem
; 277(28): 25439-45, 2002 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-11986319
20.
The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif.
J Biol Chem
; 278(34): 32219-26, 2003 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12794088