Detalhe da pesquisa
1.
Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma.
Invest New Drugs
; 38(5): 1448-1453, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32125598
2.
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.
Eur J Haematol
; 98(1): 52-56, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27301795
3.
A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells.
Br J Haematol
; 174(3): 397-409, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27098276
4.
In vitro and in vivo activity of melflufen (J1)in lymphoma.
BMC Cancer
; 16: 263, 2016 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044263
5.
Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?
Drug Resist Updat
; 21-22: 20-9, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26183292
6.
First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies.
Invest New Drugs
; 33(6): 1232-41, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26553306
7.
FGF2 as a potential prognostic biomarker for proneural glioma patients.
Acta Oncol
; 54(3): 385-94, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25263081
8.
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors.
Int J Mol Sci
; 16(11): 27313-26, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26580606
9.
The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.
Mol Pharmacol
; 85(6): 932-45, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24714215
10.
PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas.
Tumour Biol
; 35(5): 4479-88, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24510345
11.
Pharmacokinetics and Metabolism of Melflufen, an Alkylating Peptide-Drug Conjugate, in Patients with Relapsed Refractory Multiple Myeloma.
J Clin Pharmacol
; 64(2): 240-252, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37752623
12.
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.
Biochem Biophys Res Commun
; 431(2): 117-23, 2013 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23318177
13.
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.
Invest New Drugs
; 31(3): 587-98, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23179339
14.
Effects of hypoxia on human cancer cell line chemosensitivity.
BMC Cancer
; 13: 331, 2013 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23829203
15.
Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance.
BMC Cancer
; 13: 374, 2013 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23919498
16.
Expression of EGFR and LRIG proteins in oesophageal carcinoma with emphasis on patient survival and cellular chemosensitivity.
Acta Oncol
; 51(1): 69-76, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21417672
17.
Aminopeptidase N (CD13) as a target for cancer chemotherapy.
Cancer Sci
; 102(3): 501-8, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21205077
18.
Novel activity of acriflavine against colorectal cancer tumor cells.
Cancer Sci
; 102(12): 2206-13, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21910782
19.
Cytotoxic potency of small macrocyclic knot proteins: structure-activity and mechanistic studies of native and chemically modified cyclotides.
Org Biomol Chem
; 9(11): 4306-14, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21491023
20.
Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents.
Bioorg Med Chem
; 19(8): 2659-65, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21459004