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1.
J Vasc Surg Cases Innov Tech ; 9(3): 101223, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37662561

RESUMO

A new minimally invasive method for the management of catheter-related pseudoaneurysms (PSAs) using percutaneous temporary guidewire embolization (TGE) is presented. We performed percutaneous insertion of a flexible 0.018-in. guidewire into the PSA cavity under ultrasound guidance. Once thrombosis of the PSA cavity was achieved, the guidewire was removed. In all seven cases, TGE was technically feasible and achieved complete thrombosis of the PSA. The time required for PSA thrombosis from insertion to removal of the guidewire ranged from 5 to 40 minutes. TGE is a highly effective, safe, and minimally invasive treatment of PSA.

2.
Prog Cardiovasc Dis ; 73: 41-47, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35605696

RESUMO

International guidelines strongly recommend statins alone or in combination with other lipid-lowering agents to lower low-density lipoprotein cholesterol (LDL-C) levels for patients with asymptomatic/symptomatic carotid stenosis (AsxCS/SCS). Lowering LDL-C levels is associated with significant reductions in transient ischemic attack, stroke, cardiovascular (CV) event and death rates. The aim of this multi-disciplinary overview is to summarize the benefits and risks associated with lowering LDL-C with statins or non-statin medications for Asx/SCS patients. The cerebrovascular and CV beneficial effects associated with statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and other non-statin lipid-lowering agents (e.g. fibrates, ezetimibe) are reviewed. The use of statins and PCSK9 inhibitors is associated with several beneficial effects for Asx/SCS patients, including carotid plaque stabilization and reduction of stroke rates. Ezetimibe and fibrates are associated with smaller reductions in stroke rates. The side-effects resulting from statin and PCSK9 inhibitor use are also highlighted. The benefits associated with lowering LDL-C with statins or non-statin lipid lowering agents (e.g. PCSK9 inhibitors) outweigh the risks and potential side-effects. Irrespective of their LDL-C levels, all Asx/SCS patients should receive high-dose statin treatment±ezetimibe or PCSK9 inhibitors for reduction not only of LDL-C levels, but also of stroke, cardiovascular mortality and coronary event rates.


Assuntos
Anticolesterolemiantes , Doenças Cardiovasculares , Doenças das Artérias Carótidas , Inibidores de Hidroximetilglutaril-CoA Redutases , Acidente Vascular Cerebral , Anticolesterolemiantes/efeitos adversos , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/tratamento farmacológico , Doenças Cardiovasculares/prevenção & controle , Doenças das Artérias Carótidas/diagnóstico por imagem , Doenças das Artérias Carótidas/tratamento farmacológico , LDL-Colesterol , Ezetimiba/efeitos adversos , Ácidos Fíbricos , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos , Hipolipemiantes/efeitos adversos , Pró-Proteína Convertase 9
3.
Biomed Rep ; 14(1): 15, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33269076

RESUMO

Familial hypercholesterolemia (FH) is caused by mutations in various genes, including the LDLR, APOB and PSCK9 genes; however, the spectrum of these mutations in Russian individuals has not been fully investigated. In the present study, mutation screening was performed on the LDLR gene and other FH-associated genes in patients with definite or possible FH, using next-generation sequencing. In total, 59 unrelated patients were recruited and sorted into two separate groups depending on their age: Adult (n=31; median age, 49; age range, 23-70) and children/adolescent (n=28; median age, 11; age range, 2-21). FH-associated variants were identified in 18 adults and 25 children, demonstrating mutation detection rates of 58 and 89% for the adult and children/adolescent groups, respectively. In the adult group, 13 patients had FH-associated mutations in the LDLR gene, including two novel variants [NM_000527.4: c.433_434dupG p.(Val145Glyfs*35) and c.1186G>C p.(Gly396Arg)], 3 patients had APOB mutations and two had ABCG5/G8 mutations. In the children/adolescent group, 21 patients had FH-causing mutations in the LDLR gene, including five novel variants [NM_000527.4: c.325T>G p.(Cys109Gly), c.401G>C p.(Cys134Ser), c.616A>C p.(Ser206Arg), c.1684_1691delTGGCCCAA p.(Pro563Hisfs*14) and c.940+1_c.940+4delGTGA], and 2 patients had APOB mutations, as well as ABCG8 and LIPA mutations, being found in different patients. The present study reported seven novel LDLR variants considered to be pathogenic or likely pathogenic. Among them, four missense variants were located in the coding regions, which corresponded to functional protein domains, and two frameshifts were identified that produced truncated proteins. These variants were observed only once in different patients, whereas a splicing variant in intron 6 (c.940+1_c.940+4delGTGA) was detected in four unrelated individuals. Previously reported variants in the LDLR, APOB, ABCG5/8 and LIPA genes were observed in 33 patients. The LDLR p.(Gly592Glu) variant was detected in 6 patients, representing 10% of the FH cases reported in the present study, thus it may be a major variant present in the Russian population. In conclusion, the present study identified seven novel variants of the LDLR gene and broadens the spectrum of mutations in FH-related genes in the Russian Federation.

4.
Autoimmun Rev ; 4(2): 101-5, 2005 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15722256

RESUMO

It has been observed during influenza epidemics and in a number of population and clinical trials that this prevalent viral infection was associated with increased death rates from cardiovascular diseases. The clinical and experimental data that may explain accelerated coronary atherosclerosis in influenza infection with implications involving autoimmune mechanisms are reviewed in this article. Both cellular and humoral autoimmune mode could be proposed to participate in the onset or progression of atheromatous lesions due to influenza infection.


Assuntos
Autoimunidade , Doença da Artéria Coronariana/etiologia , Influenza Humana/complicações , Animais , Autoanticorpos/imunologia , Doença da Artéria Coronariana/imunologia , Humanos , Vacinas contra Influenza/administração & dosagem , Influenza Humana/prevenção & controle , Peroxidação de Lipídeos , Lipoproteínas LDL/imunologia , Mimetismo Molecular
5.
Autoimmun Rev ; 4(3): 123-9, 2005 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15823497

RESUMO

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.


Assuntos
Anti-Inflamatórios/farmacologia , Doenças Autoimunes/tratamento farmacológico , Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia , Animais , Doenças Autoimunes/imunologia , Humanos , Macrófagos/efeitos dos fármacos , Linfócitos T/efeitos dos fármacos
6.
Ann N Y Acad Sci ; 1050: 410-6, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16014558

RESUMO

It has been observed during influenza epidemics and in a number of population and clinical trials that this prevalent viral infection was associated with increased death rates from cardiovascular diseases. The clinical and experimental data that may explain accelerated coronary atherosclerosis in influenza infection with implications involving autoimmune mechanisms are analyzed in this article. Both cellular and humoral autoimmune modes could be proposed to participate in the onset or progression of atheromatous lesions due to influenza infection.


Assuntos
Autoimunidade , Doença da Artéria Coronariana/etiologia , Influenza Humana/complicações , Animais , Formação de Anticorpos , Autoanticorpos/imunologia , Doença da Artéria Coronariana/imunologia , Humanos , Imunidade Inata , Vacinas contra Influenza/administração & dosagem , Influenza Humana/prevenção & controle , Lipoproteínas LDL/imunologia , Mimetismo Molecular
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