Detalhe da pesquisa
1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125593
2.
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.
Molecules
; 24(12)2019 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31226791
3.
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Bioorg Med Chem
; 26(10): 2807-2815, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29598901
4.
Investigation of piperazine benzamides as human ß3 adrenergic receptor agonists for the treatment of overactive bladder.
Bioorg Med Chem Lett
; 27(4): 1094-1098, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28089699
5.
Discovery of benzamides as potent human ß3 adrenergic receptor agonists.
Bioorg Med Chem Lett
; 26(1): 55-9, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26590100
6.
Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.
Bioorg Med Chem Lett
; 26(19): 4743-4747, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27575474
7.
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Bioorg Med Chem Lett
; 26(23): 5695-5702, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27839686
8.
Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent.
Antimicrob Agents Chemother
; 59(6): 3474-81, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25845866
9.
Discovery of MK-7655, a ß-lactamase inhibitor for combination with Primaxin®.
Bioorg Med Chem Lett
; 24(3): 780-5, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24433862
10.
Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature
; 441(7091): 358-61, 2006 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16710421
11.
Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
J Med Chem
; 2022 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35853179
12.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
J Biol Chem
; 285(17): 12882-91, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20172854
13.
Platensimycin and platencin congeners from Streptomyces platensis.
J Nat Prod
; 74(3): 329-40, 2011 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21214253
14.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704436
15.
Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
Bioorg Med Chem Lett
; 20(16): 4757-61, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20643546
16.
Side chain SAR of bicyclic beta-lactamase inhibitors (BLIs). 1. Discovery of a class C BLI for combination with imipinem.
Bioorg Med Chem Lett
; 20(3): 918-21, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20044254
17.
Isolation, structure and biological activities of platencin A(2)-A(4) from Streptomyces platensis.
Bioorg Med Chem
; 18(7): 2602-10, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20299229
18.
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J Med Chem
; 63(22): 13796-13824, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170686
19.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 27(1): 32-40.e3, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31653597
20.
Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
Bioorg Med Chem Lett
; 19(17): 5195-9, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19632830