Detalhe da pesquisa
1.
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.
EMBO J
; 40(11): e107226, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932049
2.
Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1.
Proc Natl Acad Sci U S A
; 118(20)2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33975947
3.
Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.
Proc Natl Acad Sci U S A
; 114(13): 3439-3444, 2017 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28292906
4.
The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.
PLoS Pathog
; 13(7): e1006453, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28683142
5.
A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes.
Blood
; 127(3): 343-51, 2016 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26637786
6.
Plasmodium falciparumâ SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.
Mol Microbiol
; 96(2): 368-87, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25599609
7.
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress.
PLoS Pathog
; 9(5): e1003344, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23675297
8.
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.
Mol Microbiol
; 88(4): 687-701, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23489321
9.
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets.
bioRxiv
; 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38260474
10.
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.
J Biol Chem
; 287(45): 37949-63, 2012 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984267
11.
A multifunctional serine protease primes the malaria parasite for red blood cell invasion.
EMBO J
; 28(6): 725-35, 2009 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19214190
12.
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.
PLoS Pathog
; 7(12): e1002448, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22194692
13.
Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity.
J Med Chem
; 66(15): 10658-10680, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37505188
14.
Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery.
J Med Chem
; 65(19): 12535-12545, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36137276
15.
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite.
Elife
; 112022 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36576255
16.
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.
Infect Immun
; 79(3): 1086-97, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21220481
17.
An inhibitory antibody blocks interactions between components of the malarial invasion machinery.
PLoS Pathog
; 5(1): e1000273, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19165323
18.
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.
J Cell Biol
; 174(7): 1023-33, 2006 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-17000879
19.
Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion.
Malar J
; 9: 77, 2010 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20298576
20.
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion.
Elife
; 92020 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33287958