Detalhe da pesquisa
1.
Development of a chemical probe against NUDT15.
Nat Chem Biol
; 16(10): 1120-1128, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690945
2.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695224
3.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28447629
4.
CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation.
Nucleic Acids Res
; 40(17): 8440-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22753029
5.
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.
Cancer Res
; 80(17): 3530-3541, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32312836
6.
dUTPase inhibition augments replication defects of 5-Fluorouracil.
Oncotarget
; 8(14): 23713-23726, 2017 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28423595
7.
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Nat Med
; 23(2): 256-263, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28067901
8.
MATE2 Expression Is Associated with Cancer Cell Response to Metformin.
PLoS One
; 11(12): e0165214, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27959931
9.
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Cancer Res
; 76(18): 5501-11, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27530327
10.
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.
Cell Rep
; 14(2): 298-309, 2016 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26748709
11.
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
Nat Commun
; 6: 7871, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26238318
12.
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.
Cell Rep
; 17(12): 3407-3416, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28009306