Detalhe da pesquisa
1.
A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus.
Brain
; 147(4): 1553-1570, 2024 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38128548
2.
Structural Motifs at the Telomeres and Their Role in Regulatory Pathways.
Biochemistry
; 63(7): 827-842, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38481135
3.
Deciphering the Coevolutionary Dynamics of L2 ß-Lactamases via Deep Learning.
J Chem Inf Model
; 64(9): 3706-3717, 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687957
4.
Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease.
Brain
; 146(9): 3616-3623, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37253099
5.
The Structural Role of N170 in Substrate-Assisted Deacylation in KPC-2 ß-Lactamase.
Angew Chem Int Ed Engl
; 63(12): e202317315, 2024 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227422
6.
Control of cell surface expression of GABAA receptors by a conserved region at the end of the N-terminal extracellular domain of receptor subunits.
J Biol Chem
; 298(12): 102590, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36244453
7.
Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase.
Antimicrob Agents Chemother
; 67(11): e0079123, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37850746
8.
Blocking FSH induces thermogenic adipose tissue and reduces body fat.
Nature
; 546(7656): 107-112, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28538730
9.
Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
Proc Natl Acad Sci U S A
; 117(25): 14386-14394, 2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32513693
10.
First-in-class humanized FSH blocking antibody targets bone and fat.
Proc Natl Acad Sci U S A
; 117(46): 28971-28979, 2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127753
11.
The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer.
Molecules
; 28(6)2023 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36985425
12.
Triggered Assembly of a DNA-Based Membrane Channel.
J Am Chem Soc
; 144(10): 4333-4344, 2022 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35253434
13.
Mechanistic Insights into the Ligand-Induced Unfolding of an RNA G-Quadruplex.
J Am Chem Soc
; 144(2): 935-950, 2022 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34989224
14.
Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths.
Nucleic Acids Res
; 48(17): 9886-9898, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32453431
15.
BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers.
Nucleic Acids Res
; 48(20): 11259-11269, 2020 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33080032
16.
Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis.
Proc Natl Acad Sci U S A
; 116(30): 15116-15121, 2019 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31292255
17.
Mechanism of glucocerebrosidase activation and dysfunction in Gaucher disease unraveled by molecular dynamics and deep learning.
Proc Natl Acad Sci U S A
; 116(11): 5086-5095, 2019 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30808805
18.
Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening.
Int J Mol Sci
; 23(20)2022 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36293303
19.
Dynamic Profiling of ß-Coronavirus 3CL Mpro Protease Ligand-Binding Sites.
J Chem Inf Model
; 61(6): 3058-3073, 2021 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34124899
20.
Structure-based enzyme engineering improves donor-substrate recognition of Arabidopsis thaliana glycosyltransferases.
Biochem J
; 477(15): 2791-2805, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32657326