Joint User-Slice Pairing and Association Framework Based on H-NOMA in RAN Slicing.

Multiservice cellular in Radio Access Network (RAN) Slicing has recently attained huge interest in enhancing isolation and flexibility. However, RAN slicing in heterogeneous networks (HetNet) architecture is not adequately explored. This study proposes a pairing-network slicing (NS) approach for Multiservice RAN that cares about quality of service (QoS), baseband resources, capacities of wireless fronthaul and backhaul links, and isolation. This intriguing approach helps address the increased need for mobile network traffic produced by a range of devices with various QoS requirements, including improved dependability, ultra-reliability low-latency communications (uRLLC), and enhanced broadband Mobile Services (eMBB). Our study displays a unique RAN slicing framework for user equipment (UE) for joint user-association. Multicell non-orthogonal multiple access (NOMA)-based resource allocation across 5G HetNet under successive interference cancelation (SIC) is seen to achieve the best performance. Joint user-slice pairing and association are optimization problems to maximize eMBB UE data rates while fulfilling uRLLC latency and reliability criteria. This is accomplished by guaranteeing the inter- and intra-isolation property of slicing to eliminate interferences between eMBB and uRLLC slices. We presented the UE-slice association (U-S. A) algorithm as a one-to-many matching game to create a stable connection between UE and one of the base stations (BSs). Next, we use the UE-slice pairing (U-S. P) algorithm to find stable uRLLC-eMBB pairs that coexist on the same spectrum. Numerical findings and performance analyses of the submitted association and pairing technique show they can all be RAN slicing criteria. We prove that the proposed algorithm optimizes system throughput while decreasing uRLLC latency by associating and pairing every uRLLC user in mini slots.

A Machine Learning Approach for Movement Monitoring in Clustered Workplaces to Control COVID-19 Based on Geofencing and Fusion of Wi-Fi and Magnetic Field Metrics.

The ubiquitous existence of COVID-19 has required the management of congested areas such as workplaces. As a result, the use of a variety of inspiring tools to deal with the spread of COVID-19 has been required, including internet of things, artificial intelligence (AI), machine learning (ML), and geofencing technologies. In this work, an efficient approach based on the use of ML and geofencing technology is proposed to monitor and control the density of persons in workplaces during working hours. In particular, the workplace environment is divided into a number of geofences in which each person is associated with a set of geofences that make up their own cluster using a dynamic user-centric clustering scheme. Different metrics are used to generate a unique geofence digital signature (GDS) such as Wi-Fi basic service set identifier, Wi-Fi received signal strength indication, and magnetic field data, which can be collected using the person's smartphone. Then, these metrics are utilized by different ML techniques to generate the GDS for each indoor geofence and each building geofence as well as to detect whether the person is in their cluster. In addition, a Layered-Architecture Geofence Division method is considered to reduce the processing overhead at the person's smartphone. Our experimental results demonstrate that the proposed approach can perform well in a real workplace environment. The results show that the system accuracy is about 98.25% in indoor geofences and 76% in building geofences.

Primary arthroscopic repair of massive rotator cuff tears results in significant improvements with low rate of re-tear.

PURPOSE: To conduct a systematic review of outcomes following primary arthroscopic repair of chronic massive rotator cuff tears (RCTs) and to assess clinical outcomes and rates of repair failure. The authors' preferred treatment algorithm is also provided. METHODS: Medline, Embase and PubMed were searched identifying articles pertaining to primary arthroscopic repair of chronic massive RCTs without the use of augmentation. Primary outcomes were patient-reported outcomes and the secondary outcome was the rate of repair failure. Outcome data were pooled and presented as well as assessment of study methodological quality. Data from studies reporting similar outcome measures were pooled when possible, and mean differences alongside confidence intervals and p values were reported, where appropriate. RESULTS: Twenty-six studies (1405 participants) were included, with mean age of 62 years (range 52-69). The mean duration of symptoms pre-operatively was 31 months (range 6-40), and the mean follow-up time was 39 months (range 12-111). Complete repair was performed in 78% of patients and partial repair was performed in 22%. Both complete and partial repairs resulted in significant improvements with respect to pain, range of motion and functional outcome scores. The rate of repair failure for the total cohort was 36% at a mean follow-up of 31 months, and for the complete and partial repair subgroups the failure rate was 35% and 40%, respectively. CONCLUSIONS: Arthroscopic repairs of chronic, massive RCTs, whether complete or partial, are associated with significant improvements in pain, function and objective outcome scores. The rate of repair failure is lower than previously reported, however, still high at 36%. The present paper finds that arthroscopic repair is still a viable treatment option for massive RCTs. LEVEL OF EVIDENCE: IV.

Trajectory optimization of UAV-IRS assisted 6G THz network using deep reinforcement learning approach.

Terahertz (THz) wireless communication is a promising technology that will enable ultra-high data rates, and very low latency for future wireless communications. Intelligent Reconfigurable Surfaces (IRS) aiding Unmanned Aerial Vehicle (UAV) are two essential technologies that play a pivotal role in balancing the demands of Sixth-Generation (6G) wireless networks. In practical scenarios, mission completion time and energy consumption serve as crucial benchmarks for assessing the efficiency of UAV-IRS enabled THz communication. Achieving swift mission completion requires UAV-IRS to fly at maximum speed above the ground users it serves. However, this results in higher energy consumption. To address the challenge, this paper studies UAV-IRS trajectory planning problems in THz networks. The problem is formulated as an optimization problem aiming to minimize UAVs-IRS mission completion time by optimizing the UAV-IRS trajectory, considering the energy consumption constraint for UAVs-IRS. The proposed optimization algorithm, with low complexity, is well-suited for applications in THz communication networks. This problem is a non-convex, optimization problem that is NP-hard and presents challenges for conventional optimization techniques. To overcome this, we proposed a Deep Q-Network (DQN) reinforcement learning algorithm to enhance performance. Simulation results show that our proposed algorithm achieves performance compared to benchmark schemes.

Biomonitoring of manganese metal pollution in water and its impacts on biological activities of Biomphalaria alexandrina snail and larvicidal potencies.

Metal pollution has many dangerous environmental and human health consequences due to the bioaccumulation in the tissues. The present study aims to measure the bioaccumulation factor of the manganese (Mn) heavy metal in Biomphalaria alexandrina snails' tissues and water samples. The current results showed the concentration of Mn heavy metal in water (87.5 mg/l) and its bioaccumulation factor in Helisoma duryi tissue was higher than that in tissues of Physa acuta and B. alexandrina snails. Results showed that 87.5 mg/l Mn concentration had miracidicidal and cercaricidal activities. Also, this concentration decreased the mean total number of the hemocytes after exposure for 24 h or 48 h, while increasing both the mean mortality and phagocytic indices of the hemocytes of exposed snails. It caused alterations in the cytomorphology of the hemocytes of exposed snails after 24 or 48 h, where the granulocytes had irregular cell membranes and formed pseudopodia. Besides, levels of testosterone (T) and estradiol (E) were increased after exposure to 87.5 mg/l Mn metal compared to the control group. Also, it increased MDA (malonaldehyde) and TAC (total antioxidant capacity) contents, while decreasing SOD (superoxide dismutase). Besides, it caused significant histopathological damages in both hermaphrodite and digestive glands, represented in the degeneration of the gonadal, digestive, secretory cells, and the connective tissues. Therefore, B. alexandrina might be used as a sensitive bioindicator of pollution with Mn heavy metal to avoid ethics rules; besides, they are readily available and large in number.

Hybrid Glenoid Designs in Anatomic Total Shoulder Arthroplasty: A Systematic Review.

Background: Hybrid glenoid components in total shoulder arthroplasty (TSA) utilize both polyethylene and metal components to provide short-term stability and long-term biologic fixation through bone ingrowth. Questions/Purpose: We sought to systematically review the literature for studies that assessed outcomes of TSA performed using hybrid glenoid components. Methods: PubMed, Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Embase were searched systematically for articles measuring clinical and patient-reported outcomes and rates of complication and revision following TSA using a hybrid glenoid component. Results: Seven studies with 593 shoulders were included in this review. The mean age of patients was 65 ± 1 years, and 46% of the population was male. Mean follow-up was 50 months (4.2 years). The overall complication rate was 7% and rate of revision was 2.5%; glenoid radiolucency was present in 33% of shoulders at mean follow-up of 50 months. Mean improvements in forward elevation, external rotation, internal rotation score, and abduction were 49°, 28°, 2 points, and 42°, respectively. Mean improvements in Constant, American Shoulder and Elbow Surgeons (ASES), and University of California, Los Angeles (UCLA) scores were 36 points, 52 points, and 17 points, respectively. Conclusion: Our review found that TSA using hybrid glenoid components results in low rates of complication and revision at early follow-up. Long-term studies are warranted to understand more fully the role of hybrid glenoid components in TSA.

Anatomic total shoulder arthroplasty in rheumatoid arthritis: A systematic review.

Purpose: Given the poor soft-tissue quality in rheumatoid arthritis patients, many believe that rheumatoid arthritis should be treated with reverse total shoulder arthroplasty (rTSA). The purpose of this paper is to systematically assess outcomes of anatomic total shoulder arthroplasty (aTSA) in rheumatoid arthritis to determine if aTSA remains a viable option. Methods: A comprehensive literature search was conducted identifying articles relevant to aTSA in the setting of rheumatoid arthritis with intact rotator cuff. Outcomes include clinical outcomes and rates of complication and revision. Results: Ten studies were included with a total of 279 shoulders with mean follow-up of 116 ± 69 months. The mean age was 68 ± 10 years. Survivorship was 97%, 97% and 89% at 5, 10 and 20 years, respectively. The overall complication rate was 9%. Radiolucency was present in 69% of patients, of which 34% were at risk of loosening at 79 months. The overall rate of revision was 8.4%. Studies generally reported clinically significant improvements in range of motion, Constant score and ASES score. Conclusion: aTSA in the rheumatoid patient results in improvements in range of motion and patient-reported outcomes. Rates of complications and survivorship are generally good in this population. However, it should be noted that there is significant heterogeneity in outcome reporting amongst the literature on this topic and that many studies fail to adequately report complication and revision rates. When compared to rTSA in patients with rheumatoid arthritis, evidence suggests that aTSA is still a viable treatment option despite the shift in utilization to rTSA.

The longitudinal relationship between cannabis use and hypertension.

INTRODUCTION: The relationship between cannabis use and hypertension is not clear based on prior epidemiological studies. Thus, we examined this relationship over a 3-year follow-up period using a large population-based sample from the USA. METHODS: Self-reported longitudinal data were obtained from the National Epidemiologic Survey on Alcohol and Related Conditions Wave 1 (2001/2002) and Wave 2 (2004/2005). The sample was restricted to participants who did not report hypertension at baseline (n = 26 844; 51% 40 years and older, 51% female, 71% white). χ2 -tests were used to examine the distributions of confounders stratified by the incidence of hypertension. Thereafter, multiple logistic regression analyses were conducted to quantify the relationships between lifetime cannabis use, 12-month cannabis use and 12-month cannabis use frequency and incidence of hypertension while adjusting for confounders. RESULTS: Cannabis use was associated with a decreased incidence of hypertension in the unadjusted analyses. However, the relationships were confounded by age. After adjustment for all confounders, neither lifetime cannabis use (odds ratio, 95% confidence interval 0.89, 0.77 to 1.02), 12-month cannabis use (0.78, 0.56 to 1.09) nor 12-month cannabis use frequency [at least monthly use (0.85, 0.57 to 1.28) and less than monthly use (0.67, 0.40 to 1.11)] were associated above chance with the incidence of hypertension. DISCUSSION AND CONCLUSIONS: Lifetime cannabis use, 12-month cannabis use and 12-month cannabis use frequency were not associated with the incidence of hypertension.

Diagnosis of Obstructive Sleep Apnea during Wakefulness Using Upper Airway Negative Pressure and Machine Learning.

Background and Rational: Obstructive Sleep Apnea (OSA) is a common disorder, affecting almost 10% of adults, but very underdiagnosed. This is largely due to limited access to overnight sleep testing using polysomnography (PSG). Our goal was to distinguish OSA from healthy individual using a simple maneuver during wakefulness in combination with machine learning methods. Methods: Participants have undergone an overnight PSG to determine their ground truth OSA severity. Separately, they were asked to breathe through a nasal mask or a mouth piece through which negative pressure (NP) was applied, during wakefulness. Airflow waveforms were acquired and several features were extracted and used to train various classifiers to predict OSA. Results and Discussion: The performance of each classifier and experimental setup was calculated. The best results were obtained using Random Forest classifier for distinguishing OSA from healthy individuals with a very good area under the curve of 0.80. To the best of our knowledge, this is the first study to deploy machine learning and NP with promising path to diagnose OSA during wakefulness.

Steroid/Antiviral for the treatment of Bell's palsy: Double blind randomized clinical trial.

BACKGROUND: A large number of patients with Bell's palsy fail to recover facial function completely after steroid therapy. Only a few small trials have been conducted to test whether outcomes can be improved by the addition of antiviral therapy. OBJECTIVE: To evaluate the efficacy of treatment with steroid alone versus steroid + antiviral in a group of patients with moderately severe to severe acute Bell's palsy. METHODS: Fifty eligible patients out of a total of 65 with acute onset Bell's palsy were randomized to receive the two treatments. Evaluation was performed before starting treatment, after 2 weeks of treatment and 3 months after onset, using the House and Brackmann facial nerve grading system (HB) and the Sunnybrook grading system.This study was registered with ClinicalTrials.gov, number NCT02328079. RESULTS: Both treatments had comparable demographics and clinical scores at baseline. There was greater improvement in the mean HB and Sunnybrook scores of the steroid + antiviral group in comparison to steroid group at 3 months. At the end of the 3rd month, 17 patients (68%) had good recovery and 8 patients (32%) had poor recovery in the steroid group compared with 23 patients (92%) and 2 (8%) respectively in the steroid and antiviral group (p = 0.034). CONCLUSION: The combination of steroid and antiviral treatment increases the possibility of recovery in moderately severe to complete acute Bell's palsy.

Diagnostic accuracy of the Leishmania OligoC-TesT and NASBA-Oligochromatography for diagnosis of leishmaniasis in Sudan.

BACKGROUND: The Leishmania OligoC-TesT and NASBA-Oligochromatography (OC) were recently developed for simplified and standardised molecular detection of Leishmania parasites in clinical specimens. We here present the phase II evaluation of both tests for diagnosis of visceral leishmaniasis (VL), cutaneous leishmaniasis (CL) and post kala-azar dermal leishmaniasis (PKDL) in Sudan. METHODOLOGY: The diagnostic accuracy of the tests was evaluated on 90 confirmed and 90 suspected VL cases, 7 confirmed and 8 suspected CL cases, 2 confirmed PKDL cases and 50 healthy endemic controls from Gedarif state and Khartoum state in Sudan. PRINCIPAL FINDINGS: The OligoC-TesT as well as the NASBA-OC showed a sensitivity of 96.8% (95% CI: 83.8%-99.4%) on lymph node aspirates and of 96.2% (95% CI: 89.4%-98.7%) on blood from the confirmed VL cases. The sensitivity on bone marrow was 96.9% (95% CI: 89.3%-99.1%) and 95.3% (95% CI: 87.1%-98.4%) for the OligoC-TesT and NASBA-OC, respectively. All confirmed CL and PKDL cases were positive with both tests. On the suspected VL cases, we observed a positive OligoC-TesT and NASBA-OC result in 37.1% (95% CI: 23.2%-53.7%) and 34.3% (95% CI: 20.8%-50.9%) on lymph, in 72.7% (95% CI: 55.8%-84.9%) and 63.6% (95% CI: 46.6%-77.8%) on bone marrow and in 76.9% (95% CI: 49.7%-91.8%) and 69.2% (95% CI: 42.4%-87.3%) on blood. Seven out of 8 CL suspected cases were positive with both tests. The specificity on the healthy endemic controls was 90% (95% CI: 78.6%-95.7%) for the OligoC-TesT and 100% (95% CI: 92.9%-100.0%) for the NASBA-OC test. CONCLUSIONS: Both tests showed high sensitivity on lymph, blood and tissue scrapings for diagnosis of VL, CL and PKDL in Sudan, but the specificity for clinical VL was significantly higher with NASBA-OC.

Infection rates with Leishmania donovani and Mycobacterium tuberculosis in a village in eastern Sudan.

BACKGROUND: Leishmania-tuberculosis co-infection is not uncommon in clinical practice in East Africa, but little is known about the epidemiology of this problem at population level. A cross-sectional household survey was carried out in an active visceral leishmaniasis (VL) focus in Eastern Sudan in February 2002. METHODS: All inhabitants of Marbata village in Atbara River Area, Gedarif State, who gave informed consent, underwent both a leishmanin skin test (LST) and a tuberculin test for infection with L. donovani and Mycobacterium tuberculosis. All subjects were clinically screened for VL and tuberculosis (TB). RESULTS: About 66% (252 of 382) were LST-positive, 26% (100 of 382) were tuberculin-positive and 20% (77 of 382) were positive for both tests. By the age of 15, more than 60% of inhabitants were LST-positive, but <20% were tuberculin-positive. By the age of 30, these percentages increased to 100 and 50%. No association was found at the individual level between leishmanial and tuberculous infection after controlling for age. CONCLUSION: In this community study, we found no association between the risk of infection with L. donovani and M. tuberculosis. However, the progression to active VL disease might be different in M. tuberculosis-infected than in non-infected persons and vice versa. Prospective studies are needed to document the prognosis of TB/VL co-infection.