RESUMO
This is the first report of a t(10;17) as the unique cytogenetic finding in one case of a rare childhood tumor, clear cell sarcoma of the kidney (CCSK). This observation is discussed in relation to the cytogenetics of Wilms' tumors, of which CCSK is a variant.
Assuntos
Cromossomos Humanos Par 10 , Cromossomos Humanos Par 17 , Neoplasias Renais/genética , Sarcoma/genética , Translocação Genética , Tumor de Wilms/genética , Bandeamento Cromossômico , Marcadores Genéticos , Humanos , Lactente , Cariotipagem , Neoplasias Renais/patologia , Masculino , Sarcoma/patologia , Tumor de Wilms/patologiaRESUMO
Plasmapheresis is used for treating the complications of liver failure. We performed plasmapheresis on 6 children with hepatic encephalopathy resulting from acute hepatic failure and prospectively assessed its effects on neurologic and electrophysiologic (electroencephalography and evoked potentials) function. Clinical improvement was observed in 3 of 6 patients; changes in the serum ammonia value or the results of initial electrophysiologic tests did not predict the patient response. Two patients underwent transplantation after neurologic improvement was produced by plasmapheresis; however, despite plasmapheresis, 4 patients progressed to brain death. Our data demonstrate that plasmapheresis may transiently improve the encephalopathy of acute hepatic failure but is not curative alone. Therefore, plasmapheresis may be a useful adjunct in the treatment of liver failure, potentially improving the pretransplantation status of the patient.