Detalhe da pesquisa
1.
A novel and cost effective method of removing excess albumin from plasma/serum samples and its impacts on LC-MS/MS bioanalysis of therapeutic proteins.
Anal Chem
; 86(16): 8336-43, 2014 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25083595
2.
Pediatric model-based dose optimization using a pooled exposure-response safety analysis for nivolumab and nivolumab plus ipilimumab combination in melanoma.
CPT Pharmacometrics Syst Pharmacol
; 13(1): 168-179, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37873561
3.
Nivolumab and ipilimumab population pharmacokinetics in support of pediatric dose recommendations-Going beyond the body-size effect.
CPT Pharmacometrics Syst Pharmacol
; 13(3): 476-493, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38115545
4.
The impact of glycosylation on the pharmacokinetics of a TNFR2:Fc fusion protein expressed in Glycoengineered Pichia Pastoris.
Pharm Res
; 30(3): 803-12, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23135825
5.
Lymphatic transport and catabolism of therapeutic proteins after subcutaneous administration to rats and dogs.
Drug Metab Dispos
; 40(5): 952-62, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22328584
6.
Changing the drug development and therapeutic paradigm with biologic drug combinations and bispecifics: How to choose between these two approaches?
Clin Transl Sci
; 15(9): 2096-2104, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35611545
7.
Exposure-Response Analysis to Support Nivolumab Once Every 4 Weeks Dosing in Combination with Cabozantinib in Renal Cell Carcinoma.
Clin Cancer Res
; 28(8): 1603-1613, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34980597
8.
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo.
J Lipid Res
; 52(1): 78-86, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20959675
9.
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function.
J Biol Chem
; 285(36): 27632-40, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20581396
10.
Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences.
Drug Metab Dispos
; 39(9): 1469-77, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21610128
11.
Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: a comparative study with CHO produced materials.
Biologicals
; 39(4): 205-10, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21723741
12.
Nivolumab exposure-response analysis for adjuvant treatment of melanoma supporting a change in posology.
CPT Pharmacometrics Syst Pharmacol
; 10(7): 748-759, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33955714
13.
Nivolumab Clearance Is Stationary in Patients With Resected Melanoma on Adjuvant Therapy: Implications of Disease Status on Time-Varying Clearance.
Clin Pharmacol Ther
; 106(5): 1018-1027, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31090921
14.
Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1.
AAPS J
; 21(5): 94, 2019 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31342199
15.
Surface plasmon resonance as a tool for ligand-binding assay reagent characterization in bioanalysis of biotherapeutics.
Bioanalysis
; 10(8): 559-576, 2018 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29701071
16.
Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay.
Assay Drug Dev Technol
; 5(5): 629-36, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17939755
17.
Developing a Natural History Progression Model for Duchenne Muscular Dystrophy Using the Six-Minute Walk Test.
CPT Pharmacometrics Syst Pharmacol
; 6(9): 596-603, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28643370
18.
Perspectives on Subcutaneous Route of Administration as an Immunogenicity Risk Factor for Therapeutic Proteins.
J Pharm Sci
; 106(10): 2946-2954, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28576695
19.
Accelerating Regulated Bioanalysis for Biotherapeutics: Case Examples Using a Microfluidic Ligand Binding Assay Platform.
AAPS J
; 19(1): 82-91, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27796911
20.
Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange.
Protein Sci
; 14(12): 2982-92, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16260760