1.
Org Lett
; 26(12): 2414-2419, 2024 Mar 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38489286
RESUMO
We present an innovative photoinduced cyanoalkyl radical addition methodology using N-iminopyridinium reagents derived from cyclic ketones. Mechanistic investigations reveal the association of the excited Hantzsch ester and iminopyridinium with pyridyl radical generation. The ensuing cascade involving homolytic N-N bond and C-C bond cleavage of the pyridyl radical ultimately leads to the formation of cyanoalkyl radical species, leading to diverse Giese-type products. The method showcases versatility and synthetic utility in late-stage functionalization.