1.
Angew Chem Int Ed Engl
; 55(7): 2540-4, 2016 Feb 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26756398
RESUMO
Vinyl azide with a pendent diene can undergo thermal decomposition to a related azirine intermediate, which was used immediately in an intramolecular aza-Diels-Alder reaction to furnish an aziridine-containing trans-fused tricyclic core structure with excellent stereoselectivity. The method provides a facile entry to complex polycyclic alkaliods which can be further elaborated by ring-opening reactions and ring expansion of the aziridine moiety, as well as by dihydroxylation of the alkene group.