Detalhe da pesquisa
1.
Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study.
Lancet Oncol
; 18(1): 42-51, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27932068
2.
Brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive haematologic malignancies and hepatic or renal impairment.
Br J Clin Pharmacol
; 82(3): 696-705, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27115790
3.
Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist.
Br J Clin Pharmacol
; 79(5): 831-7, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25377933
4.
Absorption, distribution, metabolism, and excretion considerations for the development of antibody-drug conjugates.
Drug Metab Dispos
; 42(11): 1914-20, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25048520
5.
Control of acute myeloid leukemia and generation of immune memory in vivo using AMV564, a bivalent bispecific CD33 x CD3 T cell engager.
PLoS One
; 19(5): e0300174, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38696390
6.
Pharmacokinetics and tolerability of rizatriptan in pediatric migraineurs in a randomized study.
Headache
; 52(4): 625-35, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22289113
7.
Lack of effect of aprepitant or its prodrug fosaprepitant on QTc intervals in healthy subjects.
Anesth Analg
; 109(2): 418-25, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608812
8.
CYP Suppression in Human Hepatocytes by Monomethyl Auristatin E, the Payload in Brentuximab Vedotin (Adcetris®), is Associated with Microtubule Disruption.
Eur J Drug Metab Pharmacokinet
; 43(3): 347-354, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29264831
9.
Antioxidant actions of nitroxyl (HNO).
Free Radic Biol Med
; 42(4): 482-91, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17275680
10.
Nitric oxide metabolism in adults with cyanotic congenital heart disease.
Am J Cardiol
; 99(5): 691-5, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17317373
11.
Tolerability of fosaprepitant and bioequivalency to aprepitant in healthy subjects.
J Clin Pharmacol
; 47(7): 834-40, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17525168
12.
Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future.
J Clin Pharmacol
; 57 Suppl 10: S11-S25, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28921650
13.
Population Pharmacokinetics of Brentuximab Vedotin in Patients With CD30-Expressing Hematologic Malignancies.
J Clin Pharmacol
; 57(9): 1148-1158, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28513851
14.
Erythrocyte nitric oxide transport reduced by a submembrane cytoskeletal barrier.
Biochim Biophys Acta
; 1723(1-3): 135-42, 2005 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15777627
15.
CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies.
J Clin Pharmacol
; 53(8): 866-77, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754575
16.
A phase I weekly dosing study of brentuximab vedotin in patients with relapsed/refractory CD30-positive hematologic malignancies.
Clin Cancer Res
; 18(1): 248-55, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22080439
17.
The Dose Proportionality of Telcagepant after Administration of Single Oral and Intravenous Doses in Healthy Adult Subjects.
Arch Drug Inf
; 3(4): 55-62, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21221171
18.
Evaluation of the safety, pharmacokinetics and treatment effects of an alpha(nu)beta(3) integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastases.
Asia Pac J Clin Oncol
; 6(1): 42-8, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20398037
19.
Single- and multiple-dose pharmacokinetics and tolerability of telcagepant, an oral calcitonin gene-related peptide receptor antagonist, in adults.
J Clin Pharmacol
; 50(12): 1367-76, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20173082
20.
Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications.
Free Radic Biol Med
; 47(8): 1130-9, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19577638