Detalhe da pesquisa
1.
Systemically Administered Anti-uPAR Antibody Plasma and Lung ELF Pharmacokinetics Characterized by Minimal Lung PBPK Model.
AAPS PharmSciTech
; 24(8): 236, 2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37989972
2.
Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody-Drug Conjugate with Cleavable Linker.
Bioconjug Chem
; 28(2): 620-626, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28140559
3.
Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma.
Anal Chem
; 88(9): 4979-86, 2016 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27075639
4.
Human Dose and Pharmacokinetic Predictions for Biologics at Boehringer Ingelheim: A Retrospective Analysis.
Adv Ther
; 41(1): 364-378, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37971653
5.
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Bioorg Med Chem Lett
; 23(1): 209-12, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200244
6.
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Bioorg Med Chem Lett
; 23(1): 198-202, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200252
7.
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Bioorg Med Chem Lett
; 23(1): 203-8, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200249
8.
Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics.
MAbs
; 15(1): 2191301, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36998195
9.
Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager.
Front Pharmacol
; 14: 1163432, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37408756
10.
Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement.
Drug Metab Dispos
; 40(6): 1067-75, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22393119
11.
Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic.
MAbs
; 14(1): 2104153, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35916739
12.
Analyze impact of tumor-associated kinetics on antibody delivery in solid tumors with a physiologically based pharmacokinetics/pharmacodynamics model.
Eur J Pharm Biopharm
; 168: 110-121, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34478854
13.
Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5).
MAbs
; 11(5): 956-964, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31068073
14.
Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett
; 18(2): 464-8, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18178084
15.
Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Bioorg Med Chem Lett
; 18(1): 175-8, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18023581
16.
In vitro ADME phenotyping in drug discovery: current challenges and future solutions.
Curr Opin Drug Discov Devel
; 8(1): 78-88, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15679175
17.
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
J Med Chem
; 48(18): 5639-43, 2005 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16134929
18.
LC-MS/MS method development and validation for the determination of polymyxins and vancomycin in rat plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 878(28): 2831-8, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20850394
19.
Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties.
J Pharm Sci
; 99(4): 2135-52, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19780144
20.
Key bioanalytical measurements for antibody-drug conjugate development: PK/PD modelers' perspective.
Bioanalysis
; 5(9): 989-92, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23641690