Detalhe da pesquisa
1.
Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Chemistry
; 22(1): 211-21, 2016 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26578105
2.
Corrigendum: Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Chemistry
; 26(39): 8664, 2020 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32662107
3.
New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates.
Org Biomol Chem
; 7(19): 3947-57, 2009 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19763297
4.
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.
J Med Chem
; 61(4): 1622-1635, 2018 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29400470
5.
Systematic investigation of halogen bonding in protein-ligand interactions.
Angew Chem Int Ed Engl
; 50(1): 314-8, 2011 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21184410
6.
Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation.
Org Lett
; 17(13): 3222-5, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26087079
7.
Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.
J Med Chem
; 58(23): 9273-86, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26568411
8.
Halogen bonding at the active sites of human cathepsinâ L and MEK1 kinase: efficient interactions in different environments.
ChemMedChem
; 6(11): 2048-54, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21898833
9.
Self-association based on orthogonal C=O...C=O interactions in the solid and liquid state.
Chem Commun (Camb)
; 46(1): 67-9, 2010 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20024295