Detalhe da pesquisa
1.
In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10).
J Neurochem
; 129(2): 275-83, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24266811
2.
Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem Lett
; 23(6): 1684-8, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23414838
3.
Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 23(22): 6188-91, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070783
4.
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.
J Med Chem
; 62(16): 7400-7416, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31246024
5.
Characterization of the 5-HT2b receptor in evaluation of aequorin detection of calcium mobilization for miniaturized GPCR high-throughput screening.
J Biomol Screen
; 13(6): 486-93, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566482
6.
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.
Bioorg Med Chem Lett
; 18(19): 5316-9, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18774291
7.
Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers.
Bioorg Med Chem Lett
; 18(20): 5694-7, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18824351
8.
Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.
Medchemcomm
; 8(11): 2093-2099, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108726
9.
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.
J Med Chem
; 46(15): 3197-200, 2003 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12852750
10.
Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity.
J Biomol Screen
; 19(4): 595-605, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24241710
11.
BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties.
J Pharmacol Exp Ther
; 313(1): 250-9, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15608074
12.
(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.
Bioorg Med Chem Lett
; 15(2): 363-6, 2005 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15603955
13.
Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.
Bioorg Med Chem Lett
; 14(17): 4533-7, 2004 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15357987
14.
(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.
Bioorg Med Chem Lett
; 14(8): 1991-5, 2004 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15050644