Pesquisa | Portal de Pesquisa da BVS

1.

Characteristic time courses of cortical and medullary sodium signals measured by noninvasive (23) Na-MRI in rat kidney induced by furosemide.

Liu, Haiying; Zhou, Dan; Garcia, Maria L; Kohler, Martin G; Shen, Xiaolan; Williams, Donald S; Klimas, Michael T; Hargreaves, Richard J; Kaczorowski, Gregory J.

J Magn Reson Imaging ; 41(6): 1622-8, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25168165

2.

Translational PET imaging research.

Hargreaves, Richard J; Rabiner, Eugenii A.

Neurobiol Dis ; 61: 32-8, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24055214

3.

Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder.

Ball, William A; Snavely, Duane B; Hargreaves, Richard J; Szegedi, Armin; Lines, Christopher; Reines, Scott A.

Hum Psychopharmacol ; 29(6): 568-77, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25330122

4.

The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.

Addy, Carol; Wright, Hamish; Van Laere, Koen; Gantz, Ira; Erondu, Ngozi; Musser, Bret J; Lu, Kaifeng; Yuan, Jinyu; Sanabria-Bohórquez, Sandra M; Stoch, Aubrey; Stevens, Cathy; Fong, Tung M; De Lepeleire, Inge; Cilissen, Caroline; Cote, Josee; Rosko, Kim; Gendrano, Isaias N; Nguyen, Allison Martin; Gumbiner, Barry; Rothenberg, Paul; de Hoon, Jan; Bormans, Guy; Depré, Marleen; Eng, Wai-si; Ravussin, Eric; Klein, Samuel; Blundell, John; Herman, Gary A; Burns, H Donald; Hargreaves, Richard J; Wagner, John; Gottesdiener, Keith; Amatruda, John M; Heymsfield, Steven B.

Cell Metab ; 7(1): 68-78, 2008 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-18177726

5.

Evaluation of [¹8F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human.

Hostetler, Eric D; Sanabria-Bohórquez, Sandra; Eng, Waisi; Joshi, Aniket D; Patel, Shailendra; Gibson, Raymond E; O'Malley, Stacey; Krause, Stephen M; Ryan, Christine; Riffel, Kerry; Bi, Sheng; Okamoto, Osamu; Kawamoto, Hiroshi; Ozaki, Satoshi; Ohta, Hisashi; de Groot, Tjibbe; Bormans, Guy; Depré, Marleen; de Hoon, Jan; De Lepeleire, Inge; Reynders, Tom; Cook, Jacquelynn J; Burns, H Donald; Egan, Michael; Cho, William; van Laere, Koen; Hargreaves, Richard J.

Neuroimage ; 68: 1-10, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23238431

6.

In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.

Hostetler, Eric D; Joshi, Aniket D; Sanabria-Bohórquez, Sandra; Fan, Hong; Zeng, Zhizhen; Purcell, Mona; Gantert, Liza; Riffel, Kerry; Williams, Mangay; O'Malley, Stacey; Miller, Patricia; Selnick, Harold G; Gallicchio, Steven N; Bell, Ian M; Salvatore, Christopher A; Kane, Stefanie A; Li, Chi-Chung; Hargreaves, Richard J; de Groot, Tjibbe; Bormans, Guy; Van Hecken, Anne; Derdelinckx, Inge; de Hoon, Jan; Reynders, Tom; Declercq, Ruben; De Lepeleire, Inge; Kennedy, W P; Blanchard, Rebecca; Marcantonio, Eugene E; Sur, Cyrille; Cook, Jacquelynn J; Van Laere, Koen; Evelhoch, Jeffrey L.

J Pharmacol Exp Ther ; 347(2): 478-86, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23975906

7.

Why does sleep stop migraine?

Bigal, Marcelo E; Hargreaves, Richard J.

Curr Pain Headache Rep ; 17(10): 369, 2013 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-24037443

8.

Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.

Erondu, Ngozi; Gantz, Ira; Musser, Bret; Suryawanshi, Shailaja; Mallick, Madhuja; Addy, Carol; Cote, Josee; Bray, George; Fujioka, Ken; Bays, Harold; Hollander, Priscilla; Sanabria-Bohórquez, Sandra M; Eng, WaiSi; Långström, Bengt; Hargreaves, Richard J; Burns, H Donald; Kanatani, Akio; Fukami, Takehiro; MacNeil, Douglas J; Gottesdiener, Keith M; Amatruda, John M; Kaufman, Keith D; Heymsfield, Steven B.

Cell Metab ; 4(4): 275-82, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17011500

9.

Modeling effect of a Î³-secretase inhibitor on amyloid-ß dynamics reveals significant role of an amyloid clearance mechanism.

Das, Raibatak; Nachbar, Robert B; Edelstein-Keshet, Leah; Saltzman, Jeffrey S; Wiener, Matthew C; Bagchi, Ansuman; Bailey, James; Coombs, Daniel; Simon, Adam J; Hargreaves, Richard J; Cook, Jacquelynn J.

Bull Math Biol ; 73(1): 230-47, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-20411345

10.

Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes.

Ator, Nancy A; Atack, John R; Hargreaves, Richard J; Burns, H Donald; Dawson, Gerard R.

J Pharmacol Exp Ther ; 332(1): 4-16, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19789360

11.

Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.

Atack, John R; Wong, Dean F; Fryer, Tim D; Ryan, Christine; Sanabria, Sandra; Zhou, Yun; Dannals, Robert F; Eng, Wai-si; Gibson, Raymond E; Burns, H Donald; Vega, Jose M; Vessy, Laura; Scott-Stevens, Paul; Beech, John S; Baron, Jean-Claude; Sohal, Bindi; Schrag, Michael L; Aigbirhio, Franklin I; McKernan, Ruth M; Hargreaves, Richard J.

J Pharmacol Exp Ther ; 332(1): 17-25, 2010 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-19779131

12.

Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries.

Lynch, Joseph J; Regan, Christopher P; Edvinsson, Lars; Hargreaves, Richard J; Kane, Stefanie A.

J Cardiovasc Pharmacol ; 55(5): 518-21, 2010 May.

Artigo em Inglês | MEDLINE | ID: mdl-20164785

13.

In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.

Atack, John R; Maubach, Karen A; Wafford, Keith A; O'Connor, Desmond; Rodrigues, A David; Evans, David C; Tattersall, F David; Chambers, Mark S; MacLeod, Angus M; Eng, Wai-Si; Ryan, Christine; Hostetler, Eric; Sanabria, Sandra M; Gibson, Raymond E; Krause, Stephen; Burns, H Donald; Hargreaves, Richard J; Agrawal, Nancy G B; McKernan, Ruth M; Murphy, M Gail; Gingrich, Kevin; Dawson, Gerard R; Musson, Donald G; Petty, Kevin J.

J Pharmacol Exp Ther ; 331(2): 470-84, 2009 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-19704033

14.

Ten years of rizatriptan: from development to clinical science and future directions.

Hargreaves, Richard J; Lines, Chris R; Rapoport, Alan M; Ho, Tony W; Sheftell, Fred D.

Headache ; 49 Suppl 1: S3-20, 2009 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-19161563

15.

Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects.

Van Laere, Koen; Koole, Michel; Sanabria Bohorquez, Sandra M; Goffin, Karolien; Guenther, Ilonka; Belanger, Marie J; Cote, Josee; Rothenberg, Paul; De Lepeleire, Inge; Grachev, Igor D; Hargreaves, Richard J; Bormans, Guy; Burns, H Donald.

J Nucl Med ; 49(3): 439-45, 2008 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-18287275

16.

From LBR-101 to Fremanezumab for Migraine.

Bigal, Marcelo E; Rapoport, Alan M; Silberstein, Stephen D; Walter, Sarah; Hargreaves, Richard J; Aycardi, Ernesto.

CNS Drugs ; 32(11): 1025-1037, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30311143

17.

Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay.

Hershey, James C; Corcoran, Halea A; Baskin, Elizabeth P; Salvatore, Christopher A; Mosser, Scott; Williams, Theresa M; Koblan, Kenneth S; Hargreaves, Richard J; Kane, Stefanie A.

Regul Pept ; 127(1-3): 71-7, 2005 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-15680472

18.

Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant.

Bergström, Mats; Hargreaves, Richard J; Burns, H Donald; Goldberg, Michael R; Sciberras, David; Reines, Scott A; Petty, Kevin J; Ogren, Mattias; Antoni, Gunnar; Långström, Bengt; Eskola, Olli; Scheinin, Mika; Solin, Olof; Majumdar, Anup K; Constanzer, Marvin L; Battisti, Wendy P; Bradstreet, Thomas E; Gargano, Cynthia; Hietala, Jarmo.

Biol Psychiatry ; 55(10): 1007-12, 2004 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-15121485

19.

10 years of rizatriptan.

Hargreaves, Richard J.

Headache ; 49 Suppl 1: S1-2, 2009 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-19161561

20.

Non-invasive bioluminescence imaging of ß-cell function in obese-hyperglycemic [ob/ob] mice.

Patel, Manishkumar; Gleason, Alexa; O'Malley, Stacey; Connolly, Brett; Suresch, Donna; Virostko, John; Phillips, Neil; Lin, Shu-An; Chen, Tsing-Bau; Klimas, Michael; Hargreaves, Richard J; Sur, Cyrille; Williams, David L; Powers, Alvin C; Bednar, Bohumil.

PLoS One ; 9(9): e106693, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25198535

Portal de Pesquisa da BVS

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: