Detalhe da pesquisa
1.
Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity.
Chem Res Toxicol
; 37(5): 698-710, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38619497
2.
A Novel Inhaled Dry-Powder Formulation of Ribavirin Allows for Efficient Lung Delivery in Healthy Participants and Those with Chronic Obstructive Pulmonary Disease in a Phase 1 Study.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071044
3.
Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.
Drug Metab Dispos
; 48(4): 307-316, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32009006
4.
An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.
Drug Metab Dispos
; 47(12): 1457-1468, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31649125
5.
Metabolism and disposition of vilanterol, a long-acting ß(2)-adrenoceptor agonist for inhalation use in humans.
Drug Metab Dispos
; 41(1): 89-100, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043183
6.
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Chem Res Toxicol
; 25(10): 2067-82, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22931300
7.
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Clin Pharmacokinet
; 61(2): 281-293, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458976
8.
Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.
Birth Defects Res B Dev Reprod Toxicol
; 89(5): 364-75, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20717981
9.
Interrogating the relationship between rat in vivo tissue distribution and drug property data for >200 structurally unrelated molecules.
Pharmacol Res Perspect
; 3(5): e00173, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26516585
10.
Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity.
Drug Metab Dispos
; 33(2): 271-81, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15523047