Sexual Consent Norms in a Sexually Diverse Sample.

Sexual consent has received increased attention in mainstream media, educational, and political settings since the rise of the #MeToo movement in 2017. However, long before #MeToo, sexual consent has been a core practice among people who engage in Bondage and Discipline, Dominance and Submission, Sadism, and Masochism (BDSM). This study examined sexual consent norms among a sexually diverse sample, including people who practice BDSM (n = 116), people who identify with another sexual minority group, such as swingers and sex workers (n = 114), and people who did not identify with a sexual minority group, termed sexual majority group members (n = 158). Explicit consent for both BDSM- and non-BDSM-related activities was rated as more common (descriptively normative) among people who were a member of the BDSM community compared to majority participants. Further, BDSM participants rated consent discussions as less sexually disruptive compared to majority participants. We found no significant group differences in the extent to which people thought sexual consent should be discussed. We also discuss findings from an open-ended question asking participants to recall a recent sexual experience with a new partner. This study demonstrates variability in consent norms between groups and points to the potential to shift sexual consent behaviors among majority participants.

Does Sexual Desire Fluctuate More Among Women than Men?

There is a lay assumption that women's sexual desire varies substantially over time, whereas men's is stable. This assumption is mirrored in prominent theories of desire, which posit that women are more variable than men in the extent to which they desire sex, and that women's sexual desire is more contextually sensitive than men's. We tested this assumption across three longitudinal studies. Study 1 assessed desire at 3 time points spanning 13 years (Nobservations = 5562), and Studies 2 and 3 (Nobservations = 11,282) assessed desire moment-to-moment over 7 days. When desire was measured over years, women were more variable in their sexual desire than men (Study 1). However, we found a different pattern of results when desire was measured over the short term. In Studies 2 and 3, we found no significant differences in women's and men's desire variability. The extent to which desire varied as a function of affective states (e.g., happiness) and relationship-oriented states (e.g., partner closeness) was similar for women and men, with some exceptions; women's desire was more negatively associated with tiredness and anger in Study 2. These data qualify existing assumptions about sex differences in sexual desire variability.

Gender Inequities in Household Labor Predict Lower Sexual Desire in Women Partnered with Men.

Low sexual desire in women is usually studied as a problem, one that is located within women. However, other possibilities exist, including known gender inequities related to heteronormative gender roles. In this study, we provide the first test of the theory that heteronormativity is related to low sexual desire in women partnered with men, focusing specifically on inequities in the division of household labor. In two studies with women who were partnered with men and had children (Study 1, N = 677; Study 2, N = 396), performing a large proportion of household labor was associated with significantly lower sexual desire for a partner. Together, the results suggest that this association was mediated by both perceiving the partner as a dependent and perceiving the division of labor as unfair. These results support the heteronormativity theory of low sexual desire in women partnered with men, and show that gender inequities are important, though understudied, contributors to low desire in women partnered with men.

The Heteronormativity Theory of Low Sexual Desire in Women Partnered with Men.

Low sexual desire in women partnered with men is typically presumed to be a problem-one that exists in women and encourages a research agenda on causation and treatment targeting women. In this paper, we present a distinct way forward for research on low sexual desire in women partnered with men that attends to a more structural explanation: heteronormativity. A heteronormative worldview assumes that relationships and structures are heterosexual, gender (usually conflated with sex) is binary and complementary, and gender roles fit within narrow bounds including nurturant labor for women. We propose the heteronormativity theory of low sexual desire in women partnered with men, arguing that heteronormative gender inequities are contributing factors. We outline four hypotheses and their predictions related to: inequitable divisions of household labor, blurring of partner and mother roles, objectification of women, and gender norms surrounding sexual initiation. We discuss some mechanisms-social, physiological, and otherwise-for the heteronormativity theory, especially related to stress, objectification, and nurturance. We close by noting some limitations of our paper and the ways that the heteronormativity theory of low sexual desire in women partnered with men provides a rigorous, generative, and empirical way forward.

Sexual Orientation Across Porn Use, Sexual Fantasy, and In-Person Sexuality: Visualizing Branchedness and Coincidence via Sexual Configurations Theory.

Sexual orientation describes sexual interests, approaches, arousals, and attractions. People experience these interests and attractions in a number of contexts, including in-person sexuality, fantasy, and porn use, among others. The extent to which sexual orientation is divergent (branched) and/or overlapping (coincident) across these, however, is unclear. In the present study, a gender/sex and sexually diverse sample (N = 30; 15 gender/sex/ual minorities and 15 majorities) manipulated digital circles representing porn use, in-person sexuality, and fantasy on a tablet during in-person interviews. Participants used circle overlap to represent the degree of shared sexual interests across contexts and circle size to indicate the strength and/or number of sexual interests within contexts. Across multiple dimensions of sexual orientation (gender/sex, partner number, and action/behavior), we found evidence that sexual interests were both branched and coincident. These findings contribute to new understandings about the multifaceted nature of sexual orientations across contexts and provide a novel way to measure, conceptualize, and understand sexual orientation in context.

The First Dorsal Metacarpal Artery Free Flap for Salvage of Nasal Reconstructions.

ABSTRACT: The first dorsal metacarpal artery free flap is widely known for its use as a pedicled flap in thumb and hand reconstruction; however, its potential for use as a free flap is less well known. We previously described successful use of the first dorsal metacarpal artery free flap for salvage of a subtotal nasal reconstruction. In this retrospective study, we have expanded our experience to 7 consecutive cases in which a FDMFF was utilized to salvage a nasal reconstruction. Single island flaps were used in 6 of 7 cases, in one case a double island configuration was utilized. Sites restored included the columella (5 patients), membranous septum (1 patient), and nasal sidewall (1 patient). Vascular repairs were to the angular artery and vein (2 patients) or the vascular pedicle of a prior free flap (5 patients). There were no flap failures or major complications. The dorsal hand donor sites were uniformly closed using full-thickness skin grafts. All of the salvage nasal reconstructions were brought to a successful completion. Donor site morbidity was minimal with no compromise in hand function noted. Owing to its thinness, consistent anatomy, ease of harvest, and minimal donor site morbidity, the FDMFF has proved to be a very useful flap for restoration of small, but critical, nasal defects arising during the course of nasal reconstruction.

Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice†.

Inhibition of the sperm transport process in the female reproductive tract could lead to infertility. We previously showed that a pan-serine protease inhibitor, 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), blocked semen liquefaction in vivo and resulted in a drastic decrease in the number of sperm in the oviduct of female mice. In this study, we used a mouse model to test the efficacy of AEBSF as a reversible contraceptive, a sperm motility inhibitor, and a spermicide. Additionally, this study evaluated the toxicity of AEBSF on mouse vaginal tissues in vivo and human endocervical cells in vitro. We found that female mice treated with AEBSF had significantly less pups born per litter as well as fertilization rates in vivo compared to the vehicle control. We then showed that AEBSF reduced sperm motility and fertilization capability in vitro in a dose-dependent manner. Furthermore, AEBSF also exhibited spermicidal effects. Lastly, AEBSF treatment in female mice for 10 min or 3 consecutive days did not alter vaginal cell viability in vivo, similar to that of the vehicle and non-treated controls. However, AEBSF decreased cell viability of human ectocervical (ECT) cell line in vitro, suggesting that cells in the lower reproductive tract in mice and humans responded differently to AEBSF. In summary, our study showed that AEBSF can be used as a prototype compound for the further development of novel non-hormonal contraceptives for women by targeting sperm transport in the female reproductive tract.

Extracellular Vesicles and the Oviduct Function.

In mammals, the oviduct (or the Fallopian tube in humans) can be divided into the infundibulum (responsible for oocyte pick-up), ampulla (site of fertilization), isthmus (where preimplantation embryos develop), and uterotubal junction (where embryos transit to the uterus). The oviductal fluid, as well as extracellular vesicles produced from the oviduct epithelial cells, referred to as oEVs, have been shown to improve the fertilization process, prevent polyspermy, and aid in embryo development. oEVs contain molecular cargos (such as miRNAs, mRNAs, proteins, and lipids) that can be delivered and fuse to recipient cells. oEVs produced from the ampulla appear to be functionally distinct from those produced from the isthmus. In multiple species including mice, cats, dogs, pigs, and cows, oEVs can be incorporated into the oocytes, sperm, and embryos. In this review, we show the positive impact of oEVs on gamete function as well as blastocyst development and how they may improve embryo quality in in vitro conditions in an assisted reproductive technology setting for rodents, domestic animals, farm animals, and humans.

Beliefs About Gender Predict Faking Orgasm in Heterosexual Women.

The majority of women have faked an orgasm at least once in their lives. In the current study, we assessed how women's worldviews about gender relate to their faking orgasm behavior. A survey of 462 heterosexual women from the UK (Mage=38.38 years) found that those who espoused anti-feminist values-that is, those high in hostile sexism-had faked significantly more orgasms over their lifetime. In contrast, those who espoused ostensibly positive but restrictive ideas of gender relations-that is, those high in benevolent sexism-had faked significantly fewer orgasms over their lifetime. Furthermore, the more that women believed female orgasm was necessary for men's sexual gratification, the more likely they were to have faked an orgasm at least once in their lives compared to women who had never faked an orgasm. These effects were small to moderate and emerged after controlling for demographics, sexual history, ease of orgasm, and previously established psychological correlates of faking orgasm, including suspected partner infidelity and intrasexual competition.

How Much Is Enough in a Perfect World? Cultural Variation in Ideal Levels of Happiness, Pleasure, Freedom, Health, Self-Esteem, Longevity, and Intelligence.

The maximization principle-that people aspire to the highest possible level of something good if all practical constraints are removed-is a common yet untested assumption about human nature. We predict that in holistic cultures-where contradiction, change, and context are emphasized-ideal states of being for the self will be more moderate than in other cultures. In two studies ( Ns = 2,392 and 6,239), we asked this question: If participants could choose their ideal level of happiness, pleasure, freedom, health, self-esteem, longevity, and intelligence, what level would they choose? Consistent with predictions, results showed that maximization was less pronounced in holistic cultures; members of holistic cultures aspired to less happiness, pleasure, freedom, health, self-esteem, longevity, and IQ than did members of other cultures. In contrast, no differences emerged on ideals for society. The studies show that the maximization principle is not a universal aspect of human nature and that there are predictable cultural differences in people's notions of perfection.

On liking how you look and feeling sexy: Quantifying the overlap between sexual desirability and body satisfaction in a sample of Australian Grindr users.

The body image field aims to cultivate positive body image. To do so, it must appreciate factors contributing to positive body image. Sexual desirability is one such factor. Using experience sampling data from Australian Grindr users, we aimed to quantify the overlap between sexual desirability and body satisfaction. We found sexual desirability and body satisfaction correlated strongly between- (r = .90) and within-persons (rMedian =.60). Using dynamic structural equation modeling, we analyzed 238 participants' data (T = 9058), finding that sexual desirability and body satisfaction were bidirectionally related - previous sexual desirability predicted current body satisfaction (ß = 0.22) and vice versa (ß = 0.17). Participants' average body satisfaction tended to be higher when sexual desirability contributed more to body satisfaction (r = .31) and was more stable across time (r = .19). We found sexual desirability and body satisfaction overlap considerably and that sexual desirability may contribute more to body satisfaction than vice versa. Our results suggest that (1) sexual desirability and its dynamics across time influence body satisfaction, and (2) research on sexual desirability and its relationship with body image should be a focus for the field. We discuss avenues for future research on sexual desirability.

The differential effects of state and trait masculinity and femininity on body satisfaction among sexual minority men.

Masculine men are more likely to idealise being tall, muscular, and lean. Feminine men, on the other hand, are more likely to idealise leanness. At the trait level, masculinity and femininity have been linked with an unhealthy striving for these idealised traits and body dissatisfaction. However, it is unclear how feeling masculine or feminine in the moment might be associated with body satisfaction. Is feeling masculine and/or feminine associated with a boost in body satisfaction? In the first large-scale experience sampling study of masculinity and femininity (nobservations=25,133; Nparticipants=530), we find that state masculinity and femininity, but not trait, are associated with increased body satisfaction among sexual minority men. We also find a gender congruence effect whereby the positive associations between state masculinity/femininity on body satisfaction are more pronounced when these feelings align with trait levels of masculinity/femininity. Exploratory analyses revealed a moderating effect of eating disorder history. The associations between masculinity and femininity on body satisfaction were amplified for people who had been diagnosed with an eating disorder. This study presents the first evidence that the links between masculinity and femininity and body satisfaction can be delineated based on whether they are measured as traits or states.

A randomized controlled trial of a brief self-compassion intervention designed to improve the body image of sexual minority men.

Self-compassion involves reflecting on shared human experiences, expressing self-kindness, and responding to feelings in a kind and non-judgmental way. Self-compassion interventions seem to be effective for women's body dissatisfaction, however, such interventions have not been trialed with men, including sexual minority men, who are particularly vulnerable. We conducted a randomized controlled trial of a brief self-compassion intervention designed to reduce body dissatisfaction among sexual minority men (N = 605). We used a 3 (condition: self-compassion, self-esteem, and a benign recollection control) × 5 (time) repeated measures design, whereby participants completed a brief writing task and completed body image measures at multiple time-points. Participants in both the self-compassion and self-esteem conditions showed improved body image and self-compassion following the intervention whereas participants in the control condition did not. Increases in self-compassion mediated body image measures for participants in the self-compassion but not self-esteem or control conditions. Participants in the self-compassion condition also showed increased self-compassion at three-weeks follow-up. While several caveats to our results were noted, our overall interpretation is that self-compassion and self-esteem interventions might be effective for sexual minority men's body image, and more research is necessary. The challenge of inculcating a self-compassionate mindset among men is also discussed.

Evaluation of energy intake compared with indirect calorimetry requirements in critically ill patients with acute brain injury.

BACKGROUND: Nutrition support in critically ill patients with acute brain injury is vitally important because of known hypermetabolism. We aimed to describe energy and protein intake within the first 72 h in a broad neurocritical care population and compare energy intake with the indirect calorimetry (IC) resting energy expenditure (REE) target. METHODS: IC data, daily energy, and protein intake were collected through chart review over the first 7 days of hospital admission. We evaluated the type and amount of tube-feed product received, volume of propofol (1.1 kcal/ml) and clevidipine (2 kcal/ml), and amount of supplemental protein received. RESULTS: Ninety-one patients were included, with the majority presenting with either intracerebral hemorrhage (35.2%) or acute ischemic stroke (26.4%). The median day of admission on which IC was completed and enteral nutrition was initiated was day 3 (2-5) and day 1 (1-2), respectively. The difference in kilocalories received compared with IC REE target within the first 72 h was significantly different (2831 kcal [1663-4072] vs 4275 kcal [3450-5811]; Z = -6.469; P < .001). The median kilocalories received as tube feeds during the first 72 h was 88% (55%-99%), and the mean protein received in the first 72 h was 0.7 ± 0.5 g/kg/day. CONCLUSION: In this population, patients had lower energy intake compared with their energy needs determined by IC during the first 72 h of admission but attained 7-day goals. Future studies should investigate barriers to improve energy delivery in this patient population.

A patient with history of bladder cancer presenting with an axillary mass: A rare case of supradiaphragmatic cutaneous bladder cancer metastasis.

This case report documents the rare occurrence of axillary metastasis in a patient with a history of typical urothelial bladder cancer. Bladder cancer rarely metastasizes to supradiaphragmatic cutaneous tissues, and this presentation confers a poorer prognosis as well as an association with atypical variants of bladder cancer. However, this paper suggests that typical pure urothelial bladder cancer may be just as aggressive as its atypical counterpart. In addition, the work-up of axillary masses in a patient with a history of bladder cancer, whether typical or variant, should include metastatic disease as part of the differential diagnosis and guide treatment strategies.

Embodied remorse: Physical displays of remorse increase positive responses to public apologies, but have negligible effects on forgiveness.

Public apologies struggle to communicate genuineness. Previous studies have shown that, in response to public apologies, perceptions of remorse and levels of forgiveness are often low, while skepticism about motive is high. Furthermore, attempts to reduce mistrust of public apologies by manipulating the verbal component of the message have had limited success. Across 6 studies (combined N = 3,818), we examined whether people respond more positively to public apologies if the apologies are accompanied by nonverbal demonstrations of remorse: operationalized as kneeling (Studies 1 and 6) and crying (Studies 2-5). Overall, embodied remorse had small-to-medium effects on perceived remorse, and through this relationship had reliable effects on perceived likelihood of reoffending, empathy, positive appraisals of the transgressor, and satisfaction with the apology. Positive effects of embodiment emerged regardless of whether transgressions were committed by a collective (Studies 1, 2, and 6) or an individual (Studies 3-5), and were equally strong regardless of whether or not the transgressor issued an apology (Studies 4 and 5). Furthermore, embodied remorse appeared to lie beyond suspicion: if anything, those low in dispositional trust were more positively influenced by embodied remorse than those high in dispositional trust. Despite all these positive effects, embodied remorse did not have a significant effect on forgiveness in any of the studies, and an internal meta-analysis revealed a significant effect that was of negligible size. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus.

Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion of ESR1, we generated a mouse model in which Esr1 was specifically ablated during postnatal development. To accomplish this, a progesterone receptor Cre line (PgrCre) was bred with Esr1f/f mice to create conditional knockout of Esr1 in reproductive tissues (called PgrCreEsr1KO mice) beginning around 6 days after birth. In the PgrCreEsr1KO oviduct, ESR1 was most efficiently ablated in the isthmic region. We found that at 3.5 days post coitus (dpc), embryos were retrieved from the uterus in control littermates while all embryos were retained in the PgrCreEsr1KO oviduct. Additionally, serum progesterone (P4) levels were significantly lower in PgrCreEsr1KO compared to controls at 3.5 dpc. This finding suggests that expression of ESR1 in the isthmus and normal P4 levels allow for successful embryo transport from the oviduct to the uterus. Therefore, alterations in oviductal isthmus ESR1 signaling and circulating P4 levels could be related to female infertility conditions such as tubal pregnancy.

Exploring Cultural Differences in the Extent to Which People Perceive and Desire Control.

In a seminal theory piece, Weisz and colleagues argued that control over one's environment was less attainable and desirable in Japan than in America. Subsequently, many scholars have extrapolated from this argument to claim broad-based cultural differences in control: that Western/individualist cultures perceive and desire more personal control over their environment than do Eastern/collectivist cultures. Yet surprisingly little empirical research has put this claim to the test. To test this notion, in Study 1 we examined perceived control over one's life in 38 nationally representative samples ( N = 48,951). In Study 2, we measured desire for control in community samples across 27 nations ( N = 4,726). Together, the studies show lower levels of perceived and desired control in Japan than in any other nation. Over and above the Japan effect, there was no evidence for differences in perceived or desired control between individualist and collectivist nations, or between holistic and nonholistic nations.

The psychological roots of anti-vaccination attitudes: A 24-nation investigation.

OBJECTIVE: Strengthening of antivaccination movements in recent decades has coincided with unprecedented increases in the incidence of some communicable diseases. Many intervention programs work from a deficit model of science communication, presuming that vaccination skeptics lack the ability to access or understand evidence. However, interventions focusing on evidence and the debunking of vaccine-related myths have proven to be either nonproductive or counterproductive. Working from a motivated reasoning perspective, we examine the psychological factors that might motivate people to reject scientific consensus around vaccination. To assist with international generalizability, we examine this question in 24 countries. METHODS: We sampled 5,323 participants in 24 countries, and measured their antivaccination attitudes. We also measured their belief in conspiracy theories, reactance (the tendency for people to have a low tolerance for impingements on their freedoms), disgust sensitivity toward blood and needles, and individualistic/hierarchical worldviews (i.e., people's beliefs about how much control society should have over individuals, and whether hierarchies are desirable). RESULTS: In order of magnitude, antivaccination attitudes were highest among those who (a) were high in conspiratorial thinking, (b) were high in reactance, (c) reported high levels of disgust toward blood and needles, and (d) had strong individualistic/hierarchical worldviews. In contrast, demographic variables (including education) accounted for nonsignificant or trivial levels of variance. CONCLUSIONS: These data help identify the "attitude roots" that may motivate and sustain vaccine skepticism. In so doing, they help shed light on why repetition of evidence can be nonproductive, and suggest communication solutions to that problem. (PsycINFO Database Record