Detalhe da pesquisa
1.
Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication.
Mol Cell
; 82(9): 1631-1642.e6, 2022 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35316659
2.
The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate.
EMBO J
; 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38778156
3.
Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients.
J Proteome Res
; 23(3): 956-970, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38310443
4.
Expedient synthesis of imino-C-nucleoside fleximers featuring a one-pot procedure to prepare aryl triazoles.
Org Biomol Chem
; 21(30): 6134-6140, 2023 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37462413
5.
Synthesis of 12ß-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists.
Org Biomol Chem
; 20(17): 3511-3527, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35230376
6.
Synthesis of Novel C/D Ring Modified Bile Acids.
Molecules
; 27(7)2022 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35408759
7.
Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori.
Biochemistry
; 60(24): 1933-1946, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34077175
8.
Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid.
J Am Chem Soc
; 143(42): 17666-17676, 2021 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34664502
9.
Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP.
J Org Chem
; 86(13): 8843-8850, 2021 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34126010
10.
Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.
Biochemistry
; 59(27): 2562-2575, 2020 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32627538
11.
Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 114(29): 7617-7622, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679637
12.
E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function.
Gastric Cancer
; 22(2): 273-286, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30066183
13.
A Designed Approach to Enantiodivergent Enamine Catalysis.
Angew Chem Int Ed Engl
; 56(30): 8756-8760, 2017 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28544165
14.
Uncatalysed diaryldiazo cyclopropanations on bicyclic lactams: access to annulated prolines.
Org Biomol Chem
; 13(23): 6522-50, 2015 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25975925
15.
Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.
J Biol Chem
; 288(48): 34746-54, 2013 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24158442
16.
Chemoenzymatic Synthesis of 3'-Deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP).
ACS Bio Med Chem Au
; 3(4): 322-326, 2023 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37599790
17.
Galidesivir Triphosphate Promotes Stalling of Dengue-2 Virus Polymerase Immediately Prior to Incorporation.
ACS Infect Dis
; 9(8): 1658-1673, 2023 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37488090
18.
The discovery of 12ß-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists.
Eur J Med Chem
; 250: 115143, 2023 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36841086
19.
An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the Bunyavirales Order.
ACS Med Chem Lett
; 14(4): 506-513, 2023 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37077387
20.
Synthesis and use of a trifluoromethylated azomethine ylide precursor.
J Org Chem
; 77(24): 11071-8, 2012 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23176732