Detalhe da pesquisa
1.
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Mol Cell
; 73(3): 413-428.e7, 2019 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30598363
2.
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.
Proc Natl Acad Sci U S A
; 115(39): E9192-E9200, 2018 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209212
3.
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
J Immunol
; 192(12): 5476-80, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24821972
4.
Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins.
Molecules
; 21(2): 138, 2016 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26805812
5.
Recent progress on MAP kinase pathway inhibitors.
Bioorg Med Chem Lett
; 25(19): 4047-56, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26298497
6.
High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.
Bioorg Med Chem Lett
; 25(14): 2739-43, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26022841
7.
N'-[1-(2,4-Dioxo-3,4-dihydro-2H-1-benzopyran-3-yl-idene)eth-yl]thiophene-2-carbo-hydrazide.
Acta Crystallogr Sect E Struct Rep Online
; 67(Pt 4): o1014, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21754031
8.
Inhibitors of RIP1 kinase: a patent review (2016-present).
Expert Opin Ther Pat
; 31(2): 137-151, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33249869
9.
RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation.
Cell Mol Gastroenterol Hepatol
; 9(2): 295-312, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31606566
10.
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
ACS Med Chem Lett
; 10(6): 857-862, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223438
11.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
12.
The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5428-30, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18818075
13.
RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.
Cancer Cell
; 34(5): 757-774.e7, 2018 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423296
14.
Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors.
J Med Chem
; 50(18): 4453-70, 2007 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17676829
15.
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
J Exp Med
; 214(12): 3687-3705, 2017 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29089374
16.
Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.
Pharmacol Res Perspect
; 5(6)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226625
17.
Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.
Pharmacol Res Perspect
; 5(6)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226626
18.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
J Med Chem
; 60(4): 1247-1261, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28151659
19.
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
J Med Chem
; 59(5): 2163-78, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26854747
20.
Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
J Med Chem
; 48(5): 1610-9, 2005 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15743202