Detalhe da pesquisa
1.
The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands.
Int J Mol Sci
; 24(12)2023 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37373293
2.
Structureâ»Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands.
Molecules
; 24(8)2019 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013889
3.
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.
Biochim Biophys Acta Mol Basis Dis
; 1863(10 Pt A): 2414-2435, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28363699
4.
Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides.
Bioorg Med Chem Lett
; 25(24): 5708-11, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26555357
5.
A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist.
Bioorg Med Chem Lett
; 25(22): 5306-8, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26433448
6.
Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)].
ACS Pharmacol Transl Sci
; 7(4): 1114-1125, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38633589
7.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
J Med Chem
; 67(6): 4251-4258, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38456628
8.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
ACS Med Chem Lett
; 15(4): 424-431, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628790
9.
Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2')-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2')-Arg-NH2].
J Med Chem
; 66(12): 8103-8117, 2023 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37307241
10.
Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide.
ACS Omega
; 7(31): 27656-27663, 2022 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35967074
11.
Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist.
ACS Med Chem Lett
; 12(1): 115-120, 2021 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33488972
12.
Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.
ACS Chem Neurosci
; 12(3): 542-556, 2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33470098
13.
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
J Med Chem
; 64(9): 5577-5592, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33886285
14.
Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes.
J Invest Dermatol
; 141(7): 1819-1829, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33609553
15.
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.
J Med Chem
; 64(19): 14860-14875, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34592820
16.
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy.
Mol Metab
; 48: 101206, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33684608
17.
Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.
Biochemistry
; 49(22): 4583-600, 2010 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20462274
18.
Food demand and meal size in mice with single or combined disruption of melanocortin type 3 and 4 receptors.
Am J Physiol Regul Integr Comp Physiol
; 298(6): R1667-74, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20375267
19.
Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse.
FASEB J
; 23(2): 642-55, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18971258
20.
The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm.
Bioorg Med Chem
; 18(2): 580-9, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20056544