1.
Org Lett
; 8(22): 5017-20, 2006 Oct 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17048832
RESUMO
An effective screening method combining parallel synthesis and solid-state CD measurements was established to identify achiral aromatic sulfonamides that show spontaneous resolution with rapidity. We found that 4 of the 12 achiral sulfonamides crystallized as chiral crystals through this method. The chirality of each sulfonamide was discriminated by solid-state CD spectra and Flack parameter in an X-ray analysis. Correspondence between the observed Cotton effect and the absolute configuration could be confirmed by time-dependent DFT calculations. [structure: see text]
Assuntos
Química Orgânica/métodos , Sulfonamidas/química , Dicroísmo Circular , Estrutura Molecular , Sulfonamidas/síntese química
2.
J Am Chem Soc
; 129(15): 4516-7, 2007 Apr 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17385857