Detalhe da pesquisa
1.
The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion.
J Cell Physiol
; 226(8): 1970-80, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21520048
2.
Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.
Circ Res
; 104(10): 1169-77, 2009 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19390057
3.
Phosphodiesterase inhibitors: history of pharmacology.
Handb Exp Pharmacol
; (204): 1-46, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21695634
4.
Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics.
Handb Exp Pharmacol
; (204): 85-119, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21695636
5.
Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition.
J Cell Physiol
; 223(2): 317-26, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20082309
6.
The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.
Pulm Pharmacol Ther
; 23(4): 235-56, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20381629
7.
Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats.
J Pharmacol Exp Ther
; 330(1): 54-62, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19386793
8.
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia.
Crit Care Med
; 37(2): 584-90, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19114892
9.
Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition.
Cardiovasc Res
; 75(2): 390-7, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17383621
10.
Characterization of inhibitors of phosphodiesterase 1C on a human cellular system.
FEBS J
; 274(18): 4812-24, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17697115
11.
Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase.
Eur J Pharmacol
; 572(1): 12-22, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17659276
12.
The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5.
Cell Signal
; 17(3): 331-9, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15567064
13.
Novel selective PDE4 inhibitors. 3. In vivo antiinflammatory activity of a new series of N-substituted cis-tetra- and cis-hexahydrophthalazinones.
J Med Chem
; 45(12): 2520-5, 2002 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12036360
14.
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones.
J Med Chem
; 45(12): 2526-33, 2002 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12036361
15.
Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.
J Med Chem
; 46(10): 2008-16, 2003 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12723963
16.
Phosphodiesterase isoenzyme families in human osteoarthritis chondrocytes--functional importance of phosphodiesterase 4.
Br J Pharmacol
; 135(3): 609-18, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11834608
17.
The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-alpha ex vivo.
J Clin Pharmacol
; 42(3): 297-303, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11865966
18.
Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells.
Biochem Pharmacol
; 79(3): 321-9, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19737543
19.
Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.
J Immunol
; 178(8): 4820-31, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17404263
20.
PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Blood
; 107(12): 4841-8, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16514061