1.
Org Biomol Chem
; 21(43): 8658-8662, 2023 Nov 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37878244
RESUMO
We present a blueprint for the amination and defluoroamidation of α-trifluoromethylstyrene. This practical protocol presents a general method for the diversity-oriented synthesis of vicinal trifluoromethyl amines and gem-difluoro alkenes from α-trifluoromethylstyrene maintaining excellent chemoselectivity. The synthetic strategy features outstanding atom economy and wide functional group tolerance under mild reaction conditions.