Detalhe da pesquisa
1.
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicity.
Arch Toxicol
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38806719
2.
Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators.
Bioorg Med Chem Lett
; 26(23): 5741-5748, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27810243
3.
Selective Janus kinase 1 inhibition resolves inflammation and restores hair growth offering a viable treatment option for alopecia areata.
Skin Health Dis
; 3(3): e209, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37275428
4.
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
J Med Chem
; 66(19): 13400-13415, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37738648
5.
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.
Drug Des Devel Ther
; 16: 2901-2917, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36068788
6.
Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials.
Lancet Rheumatol
; 2(1): e31-e41, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258274
7.
Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators.
CPT Pharmacometrics Syst Pharmacol
; 7(3): 147-157, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29280349
8.
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J Med Chem
; 61(5): 1785-1799, 2018 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29424542
9.
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J Med Chem
; 60(20): 8591-8605, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28937774
10.
Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2.
J Med Chem
; 56(18): 7232-42, 2013 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23984907
11.
Kinetic studies on the oxidation of aryl methyl sulfides and sulfoxides by dimethyldioxirane; absolute rate constants and activation parameters for 4-nitrophenyl methyl sulfide and sulfoxide.
Org Biomol Chem
; 6(4): 762-71, 2008 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18264577
12.
An investigation by means of correlation analysis into the mechanisms of oxidation of aryl methyl sulfides and sulfoxides by dimethyldioxirane in various solvents.
Org Biomol Chem
; 6(4): 745-61, 2008 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18264576
13.
Solid-state perturbation for solubility improvement: a proof of concept.
ChemMedChem
; 6(1): 60-2, 2011 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21117133