Detalhe da pesquisa
1.
Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.
Bioorg Med Chem Lett
; 30(9): 127066, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32173198
2.
Quantitative assessment of Aß peptide in brain, cerebrospinal fluid and plasma following oral administration of γ-secretase inhibitor MRK-560 in rats.
Int J Neurosci
; 125(8): 616-24, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25567290
3.
Discovery of selective glucocorticoid receptor modulator MK-5932.
Bioorg Med Chem
; 19(24): 7374-86, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22079253
4.
Identification of potent, highly constrained CGRP receptor antagonists.
Bioorg Med Chem Lett
; 20(8): 2572-6, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20299218
5.
Laser Doppler imaging of reactive hyperemia exposes blood flow deficits in a rat model of experimental limb ischemia.
J Cardiovasc Pharmacol
; 53(6): 446-51, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19433986
6.
Eplerenone decreases inflammatory foci in spontaneously hypertensive rat hearts with minimal effects on blood pressure.
J Cardiovasc Pharmacol
; 53(1): 44-51, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19129737
7.
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
Bioorg Med Chem Lett
; 19(16): 4740-2, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19577468
8.
Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
J Pharmacol Exp Ther
; 324(2): 416-21, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18039958
9.
Development of a simplified assay for determination of the antimineralocorticoid activity of compounds dosed in rats.
J Pharmacol Toxicol Methods
; 57(2): 155-60, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18304838
10.
Potent benzimidazolone-based CGRP receptor antagonists.
Bioorg Med Chem Lett
; 18(23): 6122-5, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18947992
11.
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
J Med Chem
; 50(23): 5564-7, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17929795
12.
Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay.
Regul Pept
; 127(1-3): 71-7, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15680472
13.
The theory of "truth": how counterindustry campaigns affect smoking behavior among teens.
Health Psychol
; 24(1): 22-31, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15631559
14.
Enhanced hindlimb collateralization induced by acidic fibroblast growth factor is dependent upon femoral artery extraction.
Cardiovasc Res
; 59(4): 997-1005, 2003 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14553840
15.
The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator.
Eur J Pharmacol
; 724: 102-11, 2014 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24374007
16.
Vascular endothelial growth factor stimulates angiogenesis without improving collateral blood flow following hindlimb ischemia in rabbits.
Heart Vessels
; 18(3): 142-9, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12955430