Value of doppler ultrasonography in the study of hemodialysis peripheral vascular access dysfunction.

OBJECTIVE: The main objectives of this study were to evaluate the sensitivity and specificity of duplex Doppler ultrasonography in the study of hemodialysis peripheral vascular access dysfunction and to analyze the resistance index and flow in the afferent artery. MATERIAL AND METHODS: We prospectively studied 178 patients with 178 peripheral vascular accesses that were dysfunctional in at least three consecutive hemodialysis sessions. Patients underwent duplex Doppler ultrasonography and clinical and laboratory follow-up for three months (provided angiography findings were negative). We calculated the sensitivity, specificity, predictive values, and coefficients of probability. We studied the morphology of the afferent artery, the arteriovenous anastomosis, and the efferent vein, and we measured the resistance index and the flow of the afferent artery, the diameter of the anastomosis, and the flow and peak systolic velocity in the efferent vein. RESULTS: The final sample consisted of 159 patients. The sensitivity, specificity, positive and negative predictive values, and positive and negative coefficients of probability were 0,98 (95% CI: 0,88-1.00), 0,74 (95% CI: 0,66-0,81), 0,96, 0,82, 3.7, and 0,03, respectively. The resistance index was less than 0,5 in 78.5% of the peripheral vascular accesses with normal function and greater than 0,5 in 86.1% of the dysfunctional peripheral vascular accesses. We found aneurysms in 19 of the native peripheral vascular accesses and pseudoaneurysms in 7 of the prosthetic grafts. Inverted flow was seen in 57 peripheral vascular accesses. CONCLUSION: Duplex Doppler ultrasonography is an efficacious method for detecting and characterizing stenosis and thrombosis in peripheral vascular accesses, and it provides information about the morphology and hemodynamics.

Biometeorological and autoregressive indices for predicting olive pollen intensity.

This paper reports on modelling to predict airborne olive pollen season severity, expressed as a pollen index (PI), in Córdoba province (southern Spain) several weeks prior to the pollen season start. Using a 29-year database (1982-2010), a multivariate regression model based on five indices-the index-based model-was built to enhance the efficacy of prediction models. Four of the indices used were biometeorological indices: thermal index, pre-flowering hydric index, dormancy hydric index and summer index; the fifth was an autoregressive cyclicity index based on pollen data from previous years. The extreme weather events characteristic of the Mediterranean climate were also taken into account by applying different adjustment criteria. The results obtained with this model were compared with those yielded by a traditional meteorological-based model built using multivariate regression analysis of simple meteorological-related variables. The performance of the models (confidence intervals, significance levels and standard errors) was compared, and they were also validated using the bootstrap method. The index-based model built on biometeorological and cyclicity indices was found to perform better for olive pollen forecasting purposes than the traditional meteorological-based model.

[Bilateral vocal cord paralysis with acute airway obstruction and urgent tracheotomy in a patient with an acute vertebrobasilar stroke]. / Parálisis bilateral de las cuerdas vocales con obstrucción aguda de la vía aérea y traqueotomía urgente en una paciente con ictus vertebrobasilar agudo.

INTRODUCTION: Vertebrobasilar stroke can be a diagnostic challenge. Bilateral vocal cord paralysis is very rare as a manifestation of acute stroke, yet it is potentially life-threatening because of the possibility of acute airway obstruction. No cases of bilateral vocal cord paralysis have been reported as a presenting symptom of acute stroke of mixed central and peripheral neurological aetiology. CASE REPORT: An 88-year-old woman with dysphonia resulting from paralysis of the right vocal cord following a thyroidectomy presented with sudden onset of vertigo, dysmetria and mild dysarthria (National Institutes of Health Stroke Scale: 2) associated with arterial hypertension. An urgent brain computed tomography (CT) scan evidenced distal occlusive thrombosis of the left vertebral artery without established ischaemia. Due to the improvement of symptoms achieved with control of her blood pressure, revascularisation therapy was not performed. Four hours later, the patient suddenly developed inspiratory stridor and severe respiratory failure due to bilateral vocal cord paralysis with complete airway obstruction. An urgent tracheotomy was performed, which resulted in an improvement in her breathing. A control brain CT scan performed at 24 hours showed established infarction in the left hemicerebellum and lateral medullary region, consistent with the territory of the left posterior inferior cerebellar artery. CONCLUSION: Our case illustrates the possibility of the rare occurrence of acute bilateral vocal cord paralysis in the context of acute stroke in conjunction with chronic peripheral involvement of the recurrent laryngeal nerve. Although exceptional, it exemplifies the potential risk associated with vertebrobasilar strokes. A more aggressive reperfusion therapy may be appropriate in these cases, despite an initially mild deficit, because of the possibility of progression to life-threatening complications.

TITLE: Parálisis bilateral de las cuerdas vocales con obstrucción aguda de la vía aérea y traqueotomía urgente en una paciente con ictus vertebrobasilar agudo.Introducción. El ictus vertebrobasilar puede suponer un reto diagnóstico. La parálisis bilateral de las cuerdas vocales como manifestación de ictus agudo es muy rara, pero potencialmente mortal, por la posibilidad de obstrucción aguda de la vía aérea. No hay casos descritos de parálisis bilateral de las cuerdas vocales como presentación de ictus agudo de etiología neurológica mixta central y periférica. Caso clínico. Mujer de 88 años con disfonía secuelar a parálisis de la cuerda vocal derecha postiroidectomía que presentó un cuadro brusco de vértigo, dismetría y disartria leve (National Institutes of Health Stroke Scale: 2) asociado a hipertensión arterial. La tomografía computarizada cerebral urgente demostró trombosis distal oclusiva de la arteria vertebral izquierda sin isquemia establecida. Por mejoría sintomática con control tensional, no se realizó terapia de revascularización. Cuatro horas después, la paciente desarrolló de forma brusca estridor inspiratorio e insuficiencia respiratoria grave por parálisis bilateral de las cuerdas vocales con obstrucción completa de la vía aérea. Se realizó una traqueotomía urgente con mejoría respiratoria. Una tomografía computarizada cerebral de control a las 24 horas mostró un infarto establecido en el hemicerebelo izquierdo y la región bulbar lateral, congruente con territorio de la arteria cerebelosa posterior inferior izquierda. Conclusión. Nuestro caso ilustra la posibilidad de la rara aparición de una parálisis bilateral aguda de las cuerdas vocales en el contexto de un ictus agudo junto con una afectación periférica crónica del nervio recurrente laríngeo. Aunque es excepcional, ejemplifica el potencial riesgo asociado a los ictus vertebrobasilares. Un tratamiento más agresivo de reperfusión podría ser adecuado en estos casos, pese a un déficit inicialmente leve, por la posibilidad de progresar a complicaciones vitales.

Mechanical characterisation of hydrophobic and hydrophilic acrylates used in intraocular lenses through depth sensing indentation.

In this work, the mechanical behaviour of hydrophilic and hydrophobic acrylates has been characterised by depth sensing indentation. Time-dependent behaviour has been studied using load-relaxation tests. Experiments have been simulated with a finite element software using a visco-hyperelastic material model. The parameters of this model have been determined using deep learning techniques. The developed material models have been used to mechanically simulate a standard compression test of a prototype intraocular lens.

Incidence of contrast-induced nephropathy after a computed tomography scan.

BACKGROUND AND AIMS: The term contrast-induced nephropathy is used to describe acute deterioration of renal function after the intravenous administration of iodinated contrast material. We aimed to estimate the incidence of contrast-induced nephropathy and to analyze the evolution of different biomarkers of renal function in patients who underwent computed tomography with intravenous contrast administration after premedication with oral hydration and N-acetylcysteine. MATERIAL AND METHODS: This prospective observational study included 112 patients with chronic renal failure (glomerular filtration rate (GFR) 30ml-60ml/min/1.73m2) scheduled for computed tomography with intravenous iodinated contrast material. We recorded demographic variables, dose of contrast material, diabetes mellitus, hypertension, and serum hemoglobin. We measured serum creatinine and GFR after premedication and after the CT examination. We summarized variables as means, standard deviations, and percentages. We used the Wilcoxon and Mann-Whitney tests to compare pre- and post-CT values and Pearson's r to analyze correlations. RESULTS: Incidence acute kidney injury: 0.9%; 95%CI: 0.36-1.4. Mean difference between pre- and post-CT creatinine: 0.04; 95%CI: 0.002-0.09, p<0.004. Mean difference between pre- and post-CT GFR: -3.06; 95%CI: -4.66 to -1.47), p<0.001. CONCLUSIONS: The incidence of contrast-induced nephropathy in patients with chronic renal failure and GFR 30ml-60ml/min/1.73m2 is low. The biomarkers of renal function analyzed improve in patients who receive premedication and the minimum dose of contrast material.

[Mitochondrial acetoacetyl-CoA thiolase deficiency: neonatal onset]. / Déficit de acetoacetil-CoA tiolasa mitocondrial: inicio en el período neonatal.

We present the case of a 4-day-old newborn with serious dehydration, polypnea, hypertonus and lethargy. Blood analysis showed severe metabolic acidosis with ketonemia, ketonuria and elevation of the GAP anion. Urine analysis revealed increased excretion of 2-methyl-3-hydroxybutyrate acid, tiglycine, and 2-methylacetoacetate acid. Neonatal onset of mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is exceptional. Most patients have no clinical symptoms in the neonatal period. This entity should be considered in patients with acute metabolic acidosis and ketosis with normal glycemia and aciduria. The urine contains large amounts of 2-methylacetoacetate and its decarboxylation products. In the neonatal period, this inherited disorder of metabolism can produce severe hydroelectrolyte disorders in the form of a gradual process or acute episodes, which can occasionally be fatal.

[Imprecise status allocation by users of the American Society of Anesthesiologists classification system: survey of Catalan anesthesiologists]. / Imprecisión en la aplicación de la escala de estado físico de la American Society of Anesthesiologists: encuesta realizada entre los anestesiólogos catalanes.

OBJECTIVES: To study precision in American Society of Anesthesiologists (ASA) physical status classification by Catalan anesthesiologists. METHODS: An anonymous survey carried out in Catalonia, Spain, asked medical residents, staff anesthesiologists, and chiefs of service to allocate ASA classifications in 10 hypothetical cases that were representative of usual clinicalpractice. Respondents were also asked to state how long they had been practicing. Frequency distributions, medians and interquartile ranges (IQR) were calculated for the scores for each hypothetical case. The differences between residents and staff specialists were assessed. RESULTS: Three hundred thirty-three responses were obtained: 30.4% from residents, 59.9% from staff anesthesiologists, and 9.7% from chiefs of service. The mean (SD) length of professional practice of the staff specialists was 15.13 (8) years. For 1 case the IQR was 0 points on the ASA scale; in another case it was 3, and in the remaining cases the IQR was 1. Over half of the respondents were unfamiliar with class 6 (organ donor). The responses of residents and staff specialists for 2 cases differed significantly. CONCLUSIONS: The use of the ASA physical status scale is somewhat imprecise. There are small differences between specialists and residents and the current version is not very well known.

[Color duplex Doppler ultrasonography in the evaluation of the risk of esophageal varices bleeding in cirrhotic patients]. / Ultrasonografía Doppler dúplex color en la valoración del riesgo de sangrado por varices esofágicas en pacientes cirróticos.

The risk of variceal bleeding (VB) in patients with cirrhosis and esophageal varices may be determined by the portal pressure gradient. The value of Color Duplex Doppler Ultrasonography (CDDU) in the identification of patients at risk for variceal bleeding has been discussed in the literature. In patients with esophageal varices at risk for bleeding, CDDU did not detect patients who presented variceal bleeding during a mean follow-up of 7 months. However, patients with a low Congestion Index (< 0.05) and a mean upper portal vein velocity of > 9 were at lower risk for variceal bleeding. The Congestion Index was higher in patients with bleeding during the follow-up (0.09 vs. 0.057 (p = 0.03) and the mean portal vein velocity was lower in these patients (10.7 vs. 14).

[Approach to the scientific work of Jaume Raventós (1905-1982)]. / Aproximación a la obra científica de Jaume Raventós (1905-1982).

We analyze the scientific work done by Jaume Raventós (1905-1982) preceded by a brief biographic profile. The work of this Catalonian investigator has been separated into two stages: The first one, called the Barcelona period, is the training phase and comprises three moments: during the first one (1925-1927) the scientific participation of Raventós is still marginal; during the second period (1928-1933) he began to collaborate in large projects with A. Pi Sunyer and F. Doménech Alsina; and during the third period (1932-1934) he developed its own experimental line that culminated with his Doctoral Thesis. The second stage, called the British period, includes all work done during his exile at the United Kingdom. This phase can also be divided into three periods: the first one (1936-1939) took place in Edinburgh and was characterized by a continuation of the scientific line initiated in Barcelona; the second period developed in Manchester (1939-1954) and includes the studies with intravenous barbiturates; the third period (1956-1965) encompasses the last years of Raventós investigative activity which was devoted to the study of fluothane a new volatile anesthetic agent.

[A Spanish modification of the caudal block: S. Gil Vernet's exradural anesthesia (1917)]. / Una modificación española al bloqueo caudal: la anestesia extradural de S. Gil Vernet (1917).

This paper describes a technique for caudal epidural anesthesia proposed by S. Gil Vernet in order to achieve a high enough level of anesthesia for use in prostate surgery. The method, proposed in 1917, modified earlier work. The acceptance of the technique among other urological surgeons in Barcelona at the time is also analyzed.

[On the 150th anniversary of the introduction of anesthesia in Spain: the role of dentists]. / En el CL aniversario de la introducción de la anestesia en España: el papel de los dentistas.

We first discuss the circumstances that were influential in the role played by dentists during the early stages of anesthesia. We then study the positions of several Spanish dentists on the new technique for eliminating pain. Two opposing groups are found: on the one hand physician-dentists were cautions and prudent, and on the other, professionals with lesser qualifications such as surgeon-dentists, healers and bloodletters were clearly and boldly in favor of the new technique.

[Centenary of spinal anesthesia in Spain: first steps (1899-1904)]. / Centenario de la raquianestesia en España: los primeros pasos (1899-1904).

With the aim of commemorating the centennial of the first spinal anesthesia in Spain, we review the process followed during the early phase of application of the technique, the period associated with spinal injection of cocaine, which was the only anesthetic agent used. We describe the first trials, the influence of the Paris Congress of 1900 in spreading interest in the technique, the varied degree of acceptance by Spanish authors, and the gradual uneasiness with the procedure that arose as a result of accidents. A look at reports by Pi Sunyer and Raventós concerning possible toxic effects on the central nervous system close this overview of the earliest times of spinal anesthesia in Spain.

[E. Pi y Molist's and J.A. Reynés' memoirs on chloroform (1849): 2 forgotten classics of the Spanish bibliography on anesthesia]. / Las memorias sobre el cloroformo de E. Pi y Molist y J.A. Reynés (1849): dos clásicos olvidados de la bibliografía anestesiológica española.

This paper reviews the circumstances surrounding the first prize given in Barcelona in 1849 for a report on anesthesia. The two winning studies by the Barcelona physicians Emilio Pi y Molist and José Antonio Reynés are summarized, evaluated and compared with other similar contemporary works.

[Scientific communication in Spanish anesthesiology: medical congresses (1864-1936)]. / La comunicación científica en la anestesiología española: los congresos médicos (1864-1936).

This historical-medical study proposed to determine the evolution of knowledge in Spanish anesthesiology by examining conferences and presentations at medical congresses on record for the period between the first Spanish medical congress (1864) and the start of the Spanish Civil War (1936). We have found reports of 34 scientific meetings held during this period. All but two included news on anesthesiology or related matters. Ten were international meetings, while 25 were nation-wide conferences. We have been able to arrive at a good understanding of Spanish anesthesiology's evolution as a scientific discipline during this period.

[The creation of the first anesthesiology service in Spain (Hospital de la Santa Cruz y San Pablo, Barcelona 1941)]. / En torno a la creación del primer Servicio de Anestesiología en España (Hospital de la Santa Cruz y San Pablo, Barcelona 1941).

On the sixtieth anniversary of the founding of the first Spanish anesthesia department, we review factors that led to its creation and its early development. Hospital de la Santa Cruz y San Pablo in Barcelona was the place where the service was established for several reasons. The first was the growing need for anesthesia to be administered by specialized physicians able to handle problems developing during and after surgery. The second was the presence of a prestigious surgeon, Dr. Juan Soler Juliá, who perceived the need, alongside the only physician in Spain who was completely dedicated to anesthesiology, Dr. José Miguel Martínez. Finally, the fact that professional anesthesiology allowed a physician to earn a decent income triggered interest in the specialty among physicians.

[Changes in blood calcium during liver transplant in children]. / Variaciones de la calcemia durante el trasplante hepático pediátrico.

We have evaluated the changes in plasma total and ionic calcium levels in twenty hepatic transplantations in pediatric patients. Direct intraoperative monitoring of ionic calcium is fundamental, because its variability is unrelated with total calcium levels; in addition, normal ionic calcium levels contribute to the hemodynamic stability of the patient. Although at the end of the operation total and ionic calcium levels were similar to the postinduction measurement, their values were dissociated in the perianhepatic period. In the anhepatic phase ionic calcium reached its lowest value (1.00 mmol/l) although total calcium increased above postinduction level from 2.13 to 2.46 mmol/l (p less than 0.05). In hepatic transplantation in pediatric patients calcium administration is indicated during the transfusion of citrated blood, being particularly necessary during the anhepatic phase to prevent ionic hypocalcemia.

[Domiciliary mechanical ventilation in children: a Spanish multicentre study]. / Ventilación mecánica domiciliaria en niños: estudio multicéntrico español.

INTRODUCTION: Domiciliary mechanical ventilation (DMV) use is increasing in children. Few studies have analysed the characteristics of patients using this technique. MATERIALS AND METHODS: An observational, descriptive, transversal, multicentre study was conducted on patients between 1 month and 16 years of age dependent on domiciliary mechanical ventilation. RESULTS: A total of 163 patients with a median age of 7.6 years from 17 Spanish hospitals were studied. The main reasons for DMV were neuromuscular disorders. The median age at beginning of DMV was 4.6 years. Almost three-quarters (71.3%) received non-invasive ventilation. Patients depending on invasive ventilation were younger, started DMV at an earlier age, and had more hours of mechanical ventilation per day. The large majority (80.9%) used DMV during sleep time only, and 11.7% during the whole day. Only 3.4% of patients had external health assistance. Just under half (48.2%) were being followed up in specific DMV or multidisciplinary clinics. Almost three-quarters (72.1%) of patients attended school (42.3% with adapted schooling). Only 47.8% of school patients had specific caregivers in their schools. CONCLUSIONS: DMV in children is used in a very heterogeneous group of patients, and in an important number of patients it is started before the third year of life. Despite there being a significant proportion of patients with a high dependency on DMV, few families receive specific support at home or at school, and health care surveillance is variable and poorly coordinated.