RESUMO
OBJECTIVE: Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans. METHODS: A total of 46 representative single-nucleotide polymorphisms (SNPs) in 19 loci that were previously reported in GWAS in Europeans (including FTO and MC4R) were genotyped in 4992 subjects from six African-American cohorts. These SNPs were tested for association with body mass index (BMI) after adjustment for age, gender, disease status and population structure in each cohort. Meta-analysis was conducted to combine the results. RESULTS: Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005Assuntos
Negro ou Afro-Americano/genética
, Peso Corporal/genética
, Diabetes Mellitus Tipo 2/genética
, Obesidade/genética
, População Branca/genética
, Proteínas Adaptadoras de Transdução de Sinal/genética
, Adiposidade/genética
, Dioxigenase FTO Dependente de alfa-Cetoglutarato
, Moléculas de Adesão Celular Neuronais/genética
, Diabetes Mellitus Tipo 2/epidemiologia
, Feminino
, Proteínas Ligadas por GPI/genética
, Predisposição Genética para Doença
, Variação Genética
, Estudo de Associação Genômica Ampla
, Genótipo
, Humanos
, Masculino
, Proteínas de Membrana/genética
, Pessoa de Meia-Idade
, Obesidade/epidemiologia
, Polimorfismo de Nucleotídeo Único
, Proteínas/genética
, Receptor Tipo 4 de Melanocortina/genética
, Fatores de Transcrição