Detalhe da pesquisa
1.
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.
Nature
; 527(7577): 245-8, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26536115
2.
Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.
Bioorg Med Chem Lett
; 26(3): 936-940, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26747393
3.
Synergistic Activity of Combined NS5A Inhibitors.
Antimicrob Agents Chemother
; 60(3): 1573-83, 2015 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26711745
4.
Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore.
Oncotarget
; 12(9): 891-906, 2021 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33953843
5.
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.
J Med Chem
; 46(14): 2819-22, 2003 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12825925
6.
Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties.
J Med Chem
; 45(7): 1487-99, 2002 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-11906290
7.
Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.
Nucl Med Biol
; 29(1): 55-9, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11786276
8.
The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1730-52, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24564672
9.
Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.
J Med Chem
; 57(5): 1708-29, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24555570
10.
Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1855-79, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24397558
11.
Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception.
J Pharmacol Exp Ther
; 313(2): 840-7, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15701710
12.
The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection.
Bioorg Med Chem Lett
; 12(13): 1779-83, 2002 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12067560
13.
Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.
Bioorg Med Chem Lett
; 13(10): 1695-8, 2003 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-12729644
14.
The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.
Bioorg Med Chem Lett
; 12(7): 1117-20, 2002 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11909730
15.
The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.
Bioorg Med Chem Lett
; 14(7): 1615-8, 2004 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-15026035
16.
4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle.
Bioorg Med Chem Lett
; 14(17): 4479-82, 2004 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15357975
17.
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.
Bioorg Med Chem Lett
; 14(20): 5089-93, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380205
18.
The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.
Bioorg Med Chem Lett
; 12(7): 1023-6, 2002 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11909708