Detalhe da pesquisa
1.
The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis.
Biochem Biophys Res Commun
; 636(Pt 2): 133-140, 2022 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36368156
2.
Efficacy and safety of glecaprevir and pibrentasvir in Japanese patients with hepatitis C virus infection aged 75 years or older.
BMC Gastroenterol
; 22(1): 210, 2022 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484503
3.
Identification of novel EED-EZH2 PPI inhibitors using an in silico fragment mapping method.
J Comput Aided Mol Des
; 35(5): 601-611, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33635506
4.
Synthesis and Evaluation of a Novel Series of 2,7-Substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonists.
Chem Pharm Bull (Tokyo)
; 69(4): 333-351, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33790079
5.
Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity.
Molecules
; 25(12)2020 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32575625
6.
Characterizing the selectivity of ER α-glucosidase inhibitors.
Glycobiology
; 29(7): 530-542, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30976784
7.
A 3D-QSAR Analysis of CDK2 Inhibitors Using FMO Calculations and PLS Regression.
Chem Pharm Bull (Tokyo)
; 67(6): 546-555, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31155560
8.
(S)-1,2,3,4-Tetrahydroisoquinoline Derivatives Substituted with an Acidic Group at the 6-Position as a Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonist.
Chem Pharm Bull (Tokyo)
; 67(11): 1211-1224, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31685749
9.
In silico fragment-mapping method: a new tool for fragment-based/structure-based drug discovery.
J Comput Aided Mol Des
; 32(11): 1229-1245, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30196523
10.
Validation of molecular force field parameters for peptides including isomerized amino acids.
Chirality
; 30(4): 332-341, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29393985
11.
Linear Discriminant Analysis for the in Silico Discovery of Mechanism-Based Reversible Covalent Inhibitors of a Serine Protease: Application of Hydration Thermodynamics Analysis and Semi-empirical Molecular Orbital Calculation.
Chem Pharm Bull (Tokyo)
; 66(4): 399-409, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29607905
12.
2-Acyl-3-carboxyl-tetrahydroisoquinoline Derivatives: Mixed-Type PTP1B Inhibitors without PPARγ Activation.
Chem Pharm Bull (Tokyo)
; 66(12): 1131-1152, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30504630
13.
Design of a New α-1-C-Alkyl-DAB Derivative Acting as a Pharmacological Chaperone for ß-Glucocerebrosidase Using Ligand Docking and Molecular Dynamics Simulation.
Molecules
; 23(10)2018 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30340368
14.
In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease.
Org Biomol Chem
; 15(44): 9297-9304, 2017 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28959811
15.
A novel serine racemase inhibitor suppresses neuronal over-activation in vivo.
Bioorg Med Chem
; 25(14): 3736-3745, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533113
16.
Gibbs Free Energy of Hydrolytic Water Molecule in Acyl-Enzyme Intermediates of a Serine Protease: A Potential Application for Computer-Aided Discovery of Mechanism-Based Reversible Covalent Inhibitors.
Chem Pharm Bull (Tokyo)
; 65(10): 889-892, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28966272
17.
Novel Non-carboxylate Benzoylsulfonamide-Based Protein Tyrosine Phosphatase 1B Inhibitors with Non-competitive Actions.
Chem Pharm Bull (Tokyo)
; 65(12): 1144-1160, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29199219
18.
Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease.
Org Biomol Chem
; 14(3): 1039-48, 2016 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26633162
19.
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor.
Proc Natl Acad Sci U S A
; 110(40): 15892-7, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24043811
20.
Molecular Orbital Study of the Formation of Intramolecular Hydrogen Bonding of a Ligand Molecule in a Protein Aromatic Hydrophobic Pocket.
Chem Pharm Bull (Tokyo)
; 64(7): 1031-5, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27373666