Detalhe da pesquisa
1.
A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.
Biochem Biophys Res Commun
; 718: 149981, 2024 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38735134
2.
Exploring 2-methyl-substituted vitamin K3 derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2.
Bioorg Med Chem Lett
; 100: 129642, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38310976
3.
Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.
Biochem Biophys Res Commun
; 679: 116-121, 2023 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37683456
4.
Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity.
Bioorg Med Chem Lett
; 30(8): 127059, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32127260
5.
New Aspects of Vitamin K Research with Synthetic Ligands: Transcriptional Activity via SXR and Neural Differentiation Activity.
Int J Mol Sci
; 20(12)2019 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31226734
6.
Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity.
Molecules
; 24(20)2019 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31614668
7.
Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives.
Molecules
; 24(23)2019 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31779181
8.
Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.
Biochem Biophys Res Commun
; 483(1): 359-365, 2017 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28025137
9.
Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities.
Bioorg Med Chem Lett
; 27(21): 4881-4884, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28947152
10.
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.
Nature
; 468(7320): 117-21, 2010 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20953171
11.
YY1 positively regulates human UBIAD1 expression.
Biochem Biophys Res Commun
; 460(2): 238-44, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25772619
12.
Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.
J Biol Chem
; 288(46): 33071-80, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24085302
13.
The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes.
Hum Mutat
; 34(2): 317-29, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23169578
14.
[Elucidation of Physiological Functions of Vitamin K in the Brain and Development of New Derivatives for Neuroregeneration].
Yakugaku Zasshi
; 143(3): 199-203, 2023.
Artigo
em Japonês
| MEDLINE | ID: mdl-36858547
15.
Exploring Novel Vitamin K Derivatives with Anti-SARS-CoV-2 Activity.
ACS Omega
; 8(45): 42248-42263, 2023 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38024673
16.
SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides.
J Biochem
; 170(6): 699-711, 2022 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34244779
17.
Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification.
Front Mol Biosci
; 8: 707439, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34307463
18.
Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions.
Sci Rep
; 10(1): 5677, 2020 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32231239
19.
Acylated anthocyanins derived from purple carrot (Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole.
Food Funct
; 10(3): 1726-1735, 2019 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30848260
20.
Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes.
J Steroid Biochem Mol Biol
; 185: 71-79, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30031146