Detalhe da pesquisa
1.
Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family.
Biochem Biophys Res Commun
; 396(2): 543-8, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20435017
2.
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
J Pharmacol Exp Ther
; 333(3): 797-807, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20237073
3.
Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain.
Protein Expr Purif
; 69(1): 54-63, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19781647
4.
A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity.
SLAS Discov
; 25(4): 361-371, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585521
5.
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.
Biochemistry
; 48(27): 6402-11, 2009 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19496616
6.
Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.
J Pharmacol Exp Ther
; 331(3): 882-95, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19720877
7.
Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.
ACS Chem Biol
; 14(6): 1205-1216, 2019 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31059222
8.
Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
J Exp Med
; 215(5): 1315-1325, 2018 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29549113
9.
Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1.
Protein Pept Lett
; 19(5): 485-91, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22486643
10.
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis.
J Inflamm (Lond)
; 7: 41, 2010 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20701804
11.
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J Mol Biol
; 400(3): 413-33, 2010 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20478313