Detalhe da pesquisa
1.
Asciminib in Newly Diagnosed Chronic Myeloid Leukemia.
N Engl J Med
; 2024 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38820078
2.
Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader.
Drug Metab Dispos
; 46(9): 1268-1276, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29921707
3.
Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P1 Receptor Modulator in Healthy Subjects.
Int J Mol Sci
; 18(12)2017 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211013
4.
Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans.
Xenobiotica
; 45(2): 139-49, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25188442
5.
Effects of ponesimod, a selective S1P1 receptor modulator, on the pharmacokinetics of a hormonal combination contraceptive.
Eur J Clin Pharmacol
; 70(3): 287-93, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24362488
6.
Effects of ethnicity and sex on the pharmacokinetics and pharmacodynamics of the selective sphingosine-1-phosphate receptor 1 modulator ponesimod: a clinical study in Japanese and Caucasian subjects.
Pharmacology
; 94(5-6): 223-9, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25402365
7.
Elucidation of the metabolic pathways and the resulting multiple metabolites of almorexant, a dual orexin receptor antagonist, in humans.
Drug Metab Dispos
; 41(5): 1046-59, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23431113
8.
Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes.
J Recept Signal Transduct Res
; 33(5): 304-12, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23914782
9.
Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin.
Eur J Clin Pharmacol
; 69(6): 1235-45, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23334403
10.
Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects.
Eur J Clin Pharmacol
; 69(3): 523-32, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22990330
11.
Relative Bioavailability and Food Effect of Asciminib Pediatric Mini-tablet Formulation Compared to the Reference Tablet Formulation in Healthy Adult Participants.
Clin Pharmacol Drug Dev
; 12(5): 484-492, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36622274
12.
Asciminib monotherapy in patients with CML-CP without BCR::ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results.
Leukemia
; 37(5): 1048-1059, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36949155
13.
Absolute oral bioavailability of almorexant, a dual orexin receptor antagonist, in healthy human subjects.
Pharmacology
; 89(1-2): 53-7, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22302127
14.
Pharmacokinetic drug interactions of asciminib with the sensitive cytochrome P450 probe substrates midazolam, warfarin, and repaglinide in healthy participants.
Clin Transl Sci
; 15(6): 1406-1416, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293131
15.
Pharmacokinetics of asciminib in the presence of CYP3A or P-gp inhibitors, CYP3A inducers, and acid-reducing agents.
Clin Transl Sci
; 15(7): 1698-1712, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35616006
16.
Exposure-Efficacy Analysis of Asciminib in Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase.
Clin Pharmacol Ther
; 112(5): 1040-1050, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35776072
17.
Population Pharmacokinetics of Asciminib in Tyrosine Kinase Inhibitor-Treated Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic and Acute Phases.
Clin Pharmacokinet
; 61(10): 1393-1403, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35764773
18.
Pharmacokinetics of Asciminib When Taken With Imatinib or With Food.
Clin Pharmacol Drug Dev
; 11(2): 207-219, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34609077
19.
Pharmacokinetics and tolerability of almorexant in Japanese and Caucasian healthy male subjects.
Pharmacology
; 88(3-4): 121-6, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21865769
20.
Pharmacokinetics of Asciminib in Individuals With Hepatic or Renal Impairment.
J Clin Pharmacol
; 61(11): 1454-1465, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34115385