Detalhe da pesquisa
1.
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Nat Immunol
; 14(5): 489-99, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23563690
2.
Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A.
Mol Ther
; 29(2): 597-610, 2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33309883
3.
Immunogenicity/hypersensitivity of biologics.
Toxicol Pathol
; 42(1): 293-300, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24240973
4.
Placental transfer of a fully human IgG2 monoclonal antibody in the cynomolgus monkey, rat, and rabbit: a comparative assessment from during organogenesis to late gestation.
Birth Defects Res B Dev Reprod Toxicol
; 101(2): 178-88, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24753333
5.
Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.
Neurobiol Dis
; 49: 107-17, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22975021
6.
Transcriptional control of mitochondrial biogenesis and function.
Annu Rev Physiol
; 71: 177-203, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19575678
7.
Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise.
J Physiol
; 589(Pt 8): 2027-39, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21486805
8.
Clinical Pharmacokinetics and Pharmacodynamics of Etelcalcetide, a Novel Calcimimetic for Treatment of Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease on Hemodialysis.
J Clin Pharmacol
; 58(6): 717-726, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534286
9.
A Proposal to Redefine Clinical Immunogenicity Assessment.
AAPS J
; 19(3): 599-602, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28247192
10.
Clinical immunogenicity of the d-amino acid peptide therapeutic etelcalcetide: Method development challenges and anti-drug antibody clinical impact assessments.
J Immunol Methods
; 445: 37-44, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28274835
11.
Pharmacokinetics, Biotransformation, and Excretion of [14C]Etelcalcetide (AMG 416) Following a Single Microtracer Intravenous Dose in Patients with Chronic Kidney Disease on Hemodialysis.
Clin Pharmacokinet
; 56(2): 179-192, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27517676
12.
Immunogenicity of antibody drug conjugates: bioanalytical methods and monitoring strategy for a novel therapeutic modality.
AAPS J
; 17(1): 35-43, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380723
13.
Biomarkers for non-human primate type-I hypersensitivity: antigen-specific immunoglobulin E assays.
J Immunol Methods
; 392(1-2): 29-37, 2013 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541488
14.
Immunogenicity testing strategy and bioanalytical assays for antibody-drug conjugates.
Bioanalysis
; 5(9): 1041-55, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23641695
15.
EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.
Sci Signal
; 2(101): ra82, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20009104
16.
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
Genes Dev
; 22(2): 252-64, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18198341
17.
Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen.
J Biol Chem
; 282(37): 26897-26907, 2007 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17631495
18.
Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis.
Proc Natl Acad Sci U S A
; 104(4): 1418-23, 2007 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17229846
19.
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.
J Physiol
; 567(Pt 1): 349-58, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15961417
20.
Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness.
J Biol Chem
; 278(29): 26695-703, 2003 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12738787