Detalhe da pesquisa
1.
Synthesis and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents.
Pharm Res
; 40(1): 167-185, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36376607
2.
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies.
Bioorg Med Chem Lett
; 48: 128249, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34237441
3.
Unravelling the potency of triazole analogues for inhibiting α-synuclein fibrillogenesis and in vitro disaggregation.
Org Biomol Chem
; 19(7): 1589-1603, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33527970
4.
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease.
Bioorg Chem
; 116: 105354, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34562674
5.
Quinoline carboxamide core moiety-based compounds inhibit P. falciparumfalcipain-2: Design, synthesis and antimalarial efficacy studies.
Bioorg Chem
; 108: 104514, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33280833
6.
Deciphering the robustness of pyrazolo-pyridine carboxylate core structure-based compounds for inhibiting α-synuclein in transgenic C. elegans model of Synucleinopathy.
Bioorg Med Chem
; 28(17): 115640, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32773095
7.
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.
Bioorg Med Chem
; 27(14): 3156-3166, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176571
8.
Structure guided design of potential inhibitors of human calcium-calmodulin dependent protein kinase IV containing pyrimidine scaffold.
Bioorg Med Chem Lett
; 26(3): 782-788, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26783179
9.
Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents.
Bioorg Med Chem
; 24(12): 2777-88, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27157006
10.
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aß Aggregation for Alzheimer's Disease Therapy.
ACS Chem Neurosci
; 15(3): 539-559, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38149821
11.
Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria.
RSC Med Chem
; 15(3): 1022-1037, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38516592
12.
In silico identification of colchicine derivatives as novel and potential inhibitors based on molecular docking and dynamic simulations targeting multifactorial drug targets involved in Alzheimer's disease.
J Biomol Struct Dyn
; : 1-19, 2023 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37822182
13.
Design, synthesis, and biological evaluation of morpholinopyrimidine derivatives as anti-inflammatory agents.
RSC Adv
; 13(28): 19119-19129, 2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37383684
14.
Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents.
Eur J Med Chem
; 248: 115055, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36621136
15.
Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization.
Eur J Med Chem
; 254: 115354, 2023 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37043996
16.
Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria therapeutics.
Eur J Med Chem
; 258: 115564, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37321109
17.
Identification of new oxospiro chromane quinoline-carboxylate antimalarials that arrest parasite growth at ring stage.
J Biomol Struct Dyn
; 41(24): 15485-15506, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36970842
18.
Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach.
RSC Med Chem
; 14(12): 2768-2781, 2023 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38107179
19.
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics.
RSC Med Chem
; 13(3): 258-279, 2022 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35434628
20.
Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX.
Eur J Med Chem
; 243: 114793, 2022 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36201858