Detalhe da pesquisa
1.
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.
Cell
; 170(3): 577-592.e10, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28753431
2.
DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.
Mol Cell
; 63(4): 633-646, 2016 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27499295
3.
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
Mol Cell
; 49(1): 172-85, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142078
4.
Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.
Proc Natl Acad Sci U S A
; 115(2): E180-E189, 2018 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29269392
5.
TMEM41B is a novel regulator of autophagy and lipid mobilization.
EMBO Rep
; 19(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30126924
6.
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.
Proc Natl Acad Sci U S A
; 113(1): 182-7, 2016 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26677873
7.
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.
Proc Natl Acad Sci U S A
; 112(1): E21-9, 2015 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25524627
8.
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.
Proc Natl Acad Sci U S A
; 111(8): 3128-33, 2014 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24520176
9.
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Commun Biol
; 4(1): 736, 2021 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34127790
10.
CRISPR/Cas9-Based Chemogenomic Profiling in Mammalian Cells.
Methods Mol Biol
; 1888: 153-174, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30519946
11.
Genome-Scale CRISPR Screens Identify Human Pluripotency-Specific Genes.
Cell Rep
; 27(2): 616-630.e6, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30970262
12.
YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury.
Cell Stem Cell
; 25(1): 39-53.e10, 2019 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31080135
13.
Changes in Sef levels influence auditory brainstem development and function.
J Neurosci
; 27(16): 4273-82, 2007 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17442811
14.
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function.
BMC Cell Biol
; 9: 3, 2008 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18211691
15.
p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells.
Nat Med
; 24(7): 939-946, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29892062
16.
TRRAP is a central regulator of human multiciliated cell formation.
J Cell Biol
; 217(6): 1941-1955, 2018 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29588376
17.
Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.
Sci Rep
; 7: 42728, 2017 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28205648
18.
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.
Elife
; 52016 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27351204
19.
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science
; 351(6278): 1208-13, 2016 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26912361
20.
Signaling to the Rho GTPases: networking with the DH domain.
FEBS Lett
; 513(1): 85-91, 2002 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-11911885