Detalhe da pesquisa
1.
A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors.
Arch Pharm (Weinheim)
; 357(3): e2300583, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38110703
2.
Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies.
Mol Cancer
; 22(1): 150, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37679783
3.
Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group.
Chembiochem
; 24(6): e202300006, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36602436
4.
IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins.
Molecules
; 28(22)2023 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38005242
5.
Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein.
Molecules
; 27(23)2022 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36500376
6.
Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.
Molecules
; 27(11)2022 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35684392
7.
PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action.
Int J Mol Sci
; 22(21)2021 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34769226
8.
Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis.
Molecules
; 26(16)2021 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34443436
9.
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions.
Angew Chem Int Ed Engl
; 59(13): 5235-5241, 2020 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31944488
10.
NMR fragment-based screening for development of the CD44-binding small molecules.
Bioorg Chem
; 82: 284-289, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30396062
11.
Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles.
Molecules
; 24(11)2019 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31151293
12.
CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?
Molecules
; 24(15)2019 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31374878
13.
Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists.
Beilstein J Org Chem
; 15: 513-520, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30873235
14.
Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity.
Int J Mol Sci
; 19(9)2018 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30134556
15.
Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?
Angew Chem Int Ed Engl
; 57(18): 4840-4848, 2018 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29178534
16.
Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing.
Nature
; 474(7350): 173-8, 2011 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21614000
17.
Two-Step Synthesis of Complex Artificial Macrocyclic Compounds.
Angew Chem Int Ed Engl
; 56(36): 10725-10729, 2017 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28691783
18.
Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Angew Chem Int Ed Engl
; 56(44): 13732-13735, 2017 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28881104
19.
Shugoshin is a Mad1/Cdc20-like interactor of Mad2.
EMBO J
; 30(14): 2868-80, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21666598
20.
Conformations and Conformational Processes of Hexahydrobenzazocines by NMR and DFT Studies.
J Org Chem
; 80(18): 9231-9, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26317238