Detalhe da pesquisa
1.
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Bioorg Med Chem Lett
; 23(10): 2912-5, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562056
2.
Conformational restriction approach to ß-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Bioorg Med Chem
; 21(21): 6506-22, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24051074
3.
Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Neurodegener Dis
; 6(5-6): 230-9, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19738368
4.
Rational Design of Novel 1,3-Oxazine Based ß-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aß Reduction in the Brain.
J Med Chem
; 61(12): 5122-5137, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29733614
5.
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine ß-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.
J Med Chem
; 61(13): 5525-5546, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29775538
6.
Conformational restriction approach to ß-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
J Med Chem
; 55(20): 8838-58, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22998419
7.
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
J Neurochem
; 99(6): 1555-63, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17083447